Case Reports in Genetics, 2022 Pyridoxine dependent-developmental and epileptic encephalopathy (PD-DEE) or pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder caused by biallelic pathogenic variants in ALDH7A1.
Jiyoung Kim +4 more
doaj +1 more source
Drought Shifts Sorghum Root Metabolite and Microbiome Profiles and Enriches for Pipecolic Acid
Phytobiomes Journal, 2023 Plant-associated microbial communities shift in composition as a result of environmental perturbations, such as drought. It has been shown that Actinobacteria are enriched in plant roots and rhizospheres during drought stress.
Daniel F. Caddell +10 more
doaj +1 more source
Pipecolic acid in plants: biosynthesis, signalling, and role under stress
Botanica, 2022 Plants protect themselves by developing defensive responses against various biotic and abiotic stress factors throughout their lives. As a result, they create a stress response called ʻsystemic acquired resistance’ (SAR) under pathogen infection ...
Fatma Nur Koc, Burcu Seckin Dinler
doaj +1 more source
Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. [PDF]
PLoS ONE, 2017 Pyridoxine dependent epilepsy (PDE) is caused by likely pathogenic variants in ALDH7A1 (PDE-ALDH7A1) and inherited autosomal recessively. Neurotoxic alpha-amino adipic semialdehyde (alpha-AASA), piperideine 6-carboxylate and pipecolic acid accumulate in ...
Nikita Zabinyakov +8 more
doaj +1 more source
Metabolism of Pipecolic Acid in a Pseudomonas Species V. Pipecolate Oxidase and Dehydrogenase [PDF]
Journal of Bacteriology, 1967 Oxidation of pipecolate to Δ 1 -piperideine-6-carboxylate is catalyzed by pipecolate oxidase, an inducible, membrane-bound dehydrogenase associated with the electron transport components of Pseudomonas putida P2.
M L, Baginsky, V W, Rodwell
openaire +2 more sources
Sensitivity and specificity of salivary pipecolic acid in head and neck squamous cell carcinoma [PDF]
, 2023 Aim: The aim of the present preliminary case-control study was to test the sensitivity and specificity of salivary pipecolic acid in predicting head and neck squamous cell carcinoma (HNSCC).
Alexander Thomas +12 more
core +1 more source
Traceless Redox-Annulations of Alicyclic Amines
SynOpen, 2020 Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with ortho-(nitromethyl)benzaldehyde. Benzoic acid acts as a promoter in these reactions, which involve concurrent amine α-C–H bond and N–H bond functionalization ...
Dillon R. L. Rickertsen +4 more
doaj +1 more source
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria [PDF]
, 2013 Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and mortality remain undisputed.
Utzinger, Juerg +8 more
core +1 more source
, 2016 A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin “
John A. Porco, (2496631) +7 more
core +4 more sources
Cell-free biocatalytic syntheses of L-pipecolic acid: a dual strategy approach and process intensification in flow [PDF]
, 2020 As an alternative to the traditional chemical synthesis or in-vivo production of L-Pipecolic acid, we have developed two ex-vivo strategies using purified and immobilised enzymes for the production of this key building block.
Paradisi, Francesca +3 more
core +2 more sources