In Vitro Fertilisation of Mouse Oocytes in L-Proline and L-Pipecolic Acid Improves Subsequent Development [PDF]
Cells, 2021 Exposure of oocytes to specific amino acids during in vitro fertilisation (IVF) improves preimplantation embryo development. Embryos fertilised in medium with proline and its homologue pipecolic acid showed increased blastocyst formation and inner cell ...
Tamara Treleaven +4 more
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Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress [PDF]
The Journal of Poultry Science, 2020 L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been
Asako Shigemura +2 more
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Protective effect of L-pipecolic acid on constipation in C57BL/6 mice based on gut microbiome and serum metabolomic [PDF]
BMC Microbiology, 2023 Background Functional constipation (FC) in children affects their growth, development and quality of life. L-pipecolic acid (L-PA) was decreased in FC children based on gut microbiome and serum metabolomic.
Huan Li +6 more
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Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli [PDF]
Microbial Cell Factories, 2017 Background The six-carbon circular non-proteinogenic compound l-pipecolic acid is an important chiral drug intermediate with many applications in the pharmaceutical industry.
Hanxiao Ying +6 more
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Function of L-Pipecolic Acid as Compatible Solute in Corynebacterium glutamicum as Basis for Its Production Under Hyperosmolar Conditions [PDF]
Frontiers in Microbiology, 2019 Pipecolic acid or L-PA is a cyclic amino acid derived from L-lysine which has gained interest in the recent years within the pharmaceutical and chemical industries.
Fernando Pérez-García +2 more
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Analysis of Dynamic Changes of Scallop (Patinopecten yessoensis) Adductor Muscle and Mantle by Non-Targeted Metabolomics [PDF]
FoodsA non-targeted metabolomics technique was employed to investigate the dynamic metabolite changes of scallop (Patinopecten yessoensis) adductor muscle (SAM) and scallop mantle (SM) during the early (E), middle (M), and late (L) harvest period from June to
Di Yu +12 more
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Microbial‐derived Exerkines preserve muscle size and function during disuse in aged mice in a sex‐dependent manner [PDF]
Physiol RepAbstract Disuse‐induced muscle atrophy is a critical clinical challenge in older adults. Existing countermeasures have largely failed to preserve muscle size and function, underscoring the need for novel therapeutic strategies. We recently identified pipecolic acid and succinate (PAS) as microbial‐derived exerkines that prevent disuse‐induced atrophy ...
Daredia J +5 more
europepmc +2 more sources
Actinomycin Derivatives: Structural Diversification and Biological Activities. [PDF]
ChemMedChemActinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Can Ö, Bedir E.
europepmc +2 more sources
Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding. [PDF]
New PhytolJasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Bennett F, Stroud E, Kachroo P, Grant M.
europepmc +2 more sources
An Artificial Pathway for N-Hydroxy-Pipecolic Acid Production From L-Lysine in Escherichia coli
Frontiers in Microbiology, 2022 N-hydroxy-pipecolic acid (NHP) is a hydroxylated product of pipecolic acid and an important systemic acquired resistance signal molecule. However, the biosynthesis of NHP does not have a natural metabolic pathway in microorganisms.
Zhou Luo +10 more
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