Results 1 to 10 of about 11,010,876 (174)

Ion suppression correction and normalization for non-targeted metabolomics [PDF]

Nature Communications
Ion suppression is a major problem in mass spectrometry (MS)-based metabolomics; it can dramatically decrease measurement accuracy, precision, and sensitivity.
Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Bao Tran, Alexander Raskind, Felice de Jong, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-kin Chan, Rehan Akbani, John N. Weinstein, Chris Beecher, Philip L. Lorenzi   +15 more
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Benchmarking Non-Targeted Metabolomics Using Yeast-Derived Libraries [PDF]

Metabolites, 2021
Non-targeted analysis by high-resolution mass spectrometry (HRMS) is an essential discovery tool in metabolomics. To date, standardization and validation remain a challenge. Community-wide accepted cost-effective benchmark materials are lacking.
Evelyn Rampler, Gerrit Hermann, Gerlinde Grabmann, Yasin El Abiead, Harald Schoeny, Christoph Baumgartinger, Thomas Köcher, Gunda Koellensperger   +7 more
doaj   +4 more sources

Editorial: Emerging applications of targeted and non-targeted metabolomics to physiology and pathophysiology [PDF]

Frontiers in Physiology
Geraldine M. Dowling, Geraldine M. Dowling, Geraldine M. Dowling, Geraldine M. Dowling, Michel Aliani, Michel Aliani   +5 more
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Editorial: Current trends in targeted and non-targeted metabolomics in analytical toxicology [PDF]

Frontiers in Molecular Biosciences
Geraldine M. Dowling, Geraldine M. Dowling, Geraldine M. Dowling, Markus R. Meyer   +3 more
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Non-targeted metabolomics reveals myocardial metabolic alterations in epileptic rats. [PDF]

PLoS ONE
Sudden unexpected death in epilepsy (SUDEP) is closely associated with cardiovascular dysfunction, yet its mechanisms remain unclear. Emerging evidence suggests that epilepsy-induced cardiac dysfunction may play a central role.
Yue Hu, Yusen Wang, Qinghong Mao, Shisheng Zhu, Li Zhang   +4 more
doaj   +3 more sources

Non-targeted metabolomics reveals metabolic signatures associated with Clostridioides difficile virulence [PDF]

Frontiers in Microbiology
BackgroundClostridioides difficile (C. difficile) is a major pathogen causing antibiotic-associated diarrhea and pseudomembranous colitis, with Clostridioides difficile infection (CDI) showing a global upward trend.
Huixin Pan, Huixin Pan, Miao Zhang, Dongxiao Zhao, Qinglu Wang, Hua Shang, Ying Luo   +6 more
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Unraveling the metabolic regulation of Eleutherococcus senticosus leaves by Penicillium oxalicum: insights from targeted and non-targeted metabolomics [PDF]

BMC Plant Biology
Background The interaction between endophytic fungi and medicinal plants plays a crucial role in the production of secondary metabolites; however, the metabolic interplay between Eleutherococcus senticosus (E.
Mingyuan Xu, Yanjun Ren, Xiaotong Yang, Xiaoyue Su, Di Yang, Zhonghua Tang, Yan Liu, Lujun Li   +7 more
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Non-Targeted Metabolomics Reveal Apomorphine’s Therapeutic Effects and Lysophospholipid Alterations in Steatohepatitis [PDF]

Antioxidants
Metabolic dysfunction-associated steatohepatitis (MASH), characterized by progressive inflammation and fibrosis, evolves from metabolic dysfunction-associated steatotic liver disease and significantly heightens the risk of cirrhosis and hepatocellular ...
Hideo Ogiso, Kouichi Miura, Ryozo Nagai, Hitoshi Osaka, Kenichi Aizawa   +4 more
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Study on Differential Metabolites Between Human Papillomavirus Infection and Cervical Cancer Based on Non-Targeted Metabolomics [PDF]

International Journal of Women's Health
Jinmei Xu, Ming Wang, Yue Jia, Yanfen Chen, Yangjuan Duan, Mengting Ni, Yinghai Wang, Jie Wei, Jing Yu Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan,
Xu J, Wang M, Jia Y, Chen Y, Duan Y, Ni M, Wang Y, Wei J, Yu J   +8 more
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Identification of serum metabolic markers in non-obese hypertensive patients using non-targeted metabolomics [PDF]

Scientific Reports
The future of hypertension management lies in distinguishing disease subtypes for precise control. The underlying drivers and pathology of non-obese hypertension (J-HTN) remain unclear. There is a lack of biomarkers for the early identification of J-HTN.
Yifan Xu, Yilin Jiang, Jia Lu, Chen Xu, Qing Li, Hongjun Zhu   +5 more
doaj   +2 more sources