Peripheral neurotransmitter metabolic signatures in schizophrenia: a targeted metabolomics study [PDF]
Frontiers in PsychiatryObjectiveTo investigate peripheral metabolic alterations in patients with schizophrenia using a two-stage metabolomic workflow of untargeted analysis and targeted re-analysis,explore the associated metabolic pathways, identify potential peripheral ...
Bing Han +11 more
doaj +4 more sources
MoleculesTargeted metabolomics and lipidomics are increasingly utilized in clinical research, providing quantitative and comprehensive assessments of metabolic profiles that underlie physiological and pathological mechanisms.
Nguyen Phuoc Long +2 more
exaly +4 more sources
Molecules, 2022 The authors of this paper conducted a comparative metabolomic analysis of Ophiocordyceps sinensis (OS), providing the metabolic profiles of the stroma (OSBSz) and sclerotia (OSBSh) of OS by widely targeted metabolomics and untargeted metabolomics.
Jinna Zhou +6 more
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Investigation of pathogenesis of hyperuricemia based on untargeted and targeted metabolomics
Scientific Reports, 2022 Hyperuricemia (HUA) seriously harms human health but the exact etiology and pathogenesis of HUA are not fully understood. Therefore, it is still of great significance to find effective biomarkers and explore the pathogenesis of HUA. Metabolomics reflects
Nankun Qin +8 more
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Development, characterization and comparisons of targeted and non-targeted metabolomics methods [PDF]
PLoS ONE, 2018 The potential of a metabolomics method to detect statistically significant perturbations in the metabolome of an organism is enhanced by excellent analytical precision, unequivocal identification, and broad metabolomic coverage.
Jonathan P Benskin +2 more
exaly +2 more sources
Integrated non-targeted and targeted metabolomics reveals tryptophan metabolism disorders in hypertension [PDF]
Frontiers in Cardiovascular MedicineObjectiveThis study aimed to characterize serum metabolic profiles in hypertensive patients and investigate the regulatory role of tryptophan metabolism.MethodsWe employed an integrated metabolomics strategy that combined non-targeted screening with ...
Jing-wen Yue +7 more
doaj +2 more sources
ACS Measurement Science Au, 2021 The thousands of features commonly observed when performing untargeted metabolomics with quadrupole time-of-flight (QTOF) and Orbitrap mass spectrometers often correspond to only a few hundred unique metabolites of biological origin, which is in the ...
Bharat Thyagarajan +2 more
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Metabolic differences among patients with alcohol-related liver disease using targeted and untargeted metabolomics techniques [PDF]
Egyptian Liver JournalBackground Alcoholic liver disease (ALD) represents a significant global public health challenge. Aims This study aims to investigate the metabolic characteristics of ALD through metabolomics technology.
Jie Lu +5 more
doaj +2 more sources
Integrated untargeted and targeted metabolomics identifies and validates urinary bile acid biomarkers for the diagnosis of intrahepatic cholestasis of pregnancy [PDF]
Front Endocrinol (Lausanne)You H +8 more
europepmc +3 more sources
Metabolic signatures and diagnostic models of ischemic stroke and its hypertensive subtype: a non-targeted metabolomics and machine learning [PDF]
Front GenetKong X, Zhang L, Li X, Zhou Q.
europepmc +2 more sources