Results 11 to 20 of about 90,676 (185)

Targeted Metabolomics for Biomarker Discovery [PDF]

Angewandte Chemie International Edition, 2010
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis.
Hans-Peter Deigner, David P. Enot, Matthias Kohl, Enot, David P., Yuqin Wang, Koal, Therese, William Griffiths, Therese Koal, William J. Griffiths, Wang, Yuqin, Griffiths, William J., Kohl, Matthias, Deigner, Hans-Peter   +12 more
core   +4 more sources

Isotopologue ratio normalization for non-targeted metabolomics [PDF]

Journal of Chromatography A, 2015
peer reviewedRobust quantification of analytes is a prerequisite for meaningful metabolomics experiments. In non-targeted metabolomics it is still hard to compare measurements across multiple batches or instruments. For targeted analyses isotope dilution
HILLER, Karsten, WEGNER, André, WEINDL, Daniel, Jäger, Christian   +3 more
core   +4 more sources

Simultaneous Quantitation and Discovery (SQUAD) Analysis: Combining the Best of Targeted and Untargeted Mass Spectrometry-Based Metabolomics [PDF]

Metabolites, 2023
Untargeted and targeted approaches are the traditional metabolomics workflows acquired for a wider understanding of the metabolome under focus. Both approaches have their strengths and weaknesses.
Bashar Amer, Rahul R. Deshpande, Susan S. Bird   +2 more
doaj   +2 more sources

Hyphenated MS–Based Targeted approaches in metabolomics [PDF]

The Analyst, 2017
While global metabolic profiling (untargeted metabolomics) has been the center of much interest and research activity in the past few decades, more recently targeted metabolomics approaches have begun to gain ground.
H. G. Gika, O. Begou, G. Theodoridis, Theodoridis, G, Wilson, ID, Gika, HG, Begou, O, I. D. Wilson   +7 more
core   +5 more sources

Targeted metabolomics for bioprocessing [PDF]

BMC Proceedings, 2011
Background Bioprocesses like the cell-based production of biologicals, i.e. mainly recombinant proteins and monoclonal antibodies, require optimal culture conditions to obtain a high yield of quality products. The performance of a bioreactor highly depends on the cell characteristics as well as on the composition of the cell culture medium and the ...
Sonntag Denise, Scandurra Francesca M, Friedrich Torben, Urban Michael, Weinberger Klaus M   +4 more
doaj   +3 more sources

Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach [PDF]

Smart Medicine
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives.
Lidan Hu, Yifan Zhu, Chengpeng Wu, Xiao Liu, Qi Wang, Yangyiyi Huang, Hongyan Liu, Xiangjun Chen, Wei Wu, Hua Jiang   +9 more
doaj   +2 more sources

Targeted Metabolomics [PDF]

Current Protocols in Molecular Biology, 2012
AbstractThe metabolome is the terminal downstream product of the genome and consists of the total complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or organism. Metabolomics aims to measure a wide breadth of small molecules in the context of physiological stimuli or disease states.
Lee D, Roberts, Amanda L, Souza, Robert E, Gerszten, Clary B, Clish   +3 more
openaire   +2 more sources

Metabolome of canine and human saliva: a non-targeted metabolomics study [PDF]

Metabolomics, 2020
Abstract Introduction Saliva metabolites are suggested to reflect the health status of an individual in humans. The same could be true with the dog (Canis lupus familiaris), an important animal model of human disease, but its saliva metabolome is unknown.
Soile Turunen, Jenni Puurunen, Seppo Auriola, Arja M. Kullaa, Olli Kärkkäinen, Hannes Lohi, Kati Hanhineva   +6 more
openaire   +4 more sources

Targeting of the Hydrophobic Metabolome by Pathogens [PDF]

Traffic, 2015
The hydrophobic molecules of the metabolome – also named the lipidome – constitute a major part of the entire metabolome. Novel technologies show the existence of a staggering number of individual lipid species, the biological functions of which are, with the exception of only a few lipid species, unknown.
Helms, Bernd, Kaloyanova, Dora V, Strating, Jeroen R P, van Hellemond, Jaap J, van der Schaar, Hilde M, Tielens, Aloysius G M, van Kuppeveld, Frank J M, Brouwers, Jos F   +7 more
openaire   +3 more sources

The Hitchhiker’s Guide to Statistical Analysis of Feature-based Molecular Networks from Non-Targeted Metabolomics Data [PDF]

, 2023
Feature-Based Molecular Networking (FBMN) is a popular analysis approach for LC-MS/MS-based non-targeted metabolomics data. While processing LC-MS/MS data through FBMN is fairly streamlined, downstream data handling and statistical interrogation is often
Corinna, Brungs, Hannes, Link, Pieter C., Dorrestein, Allegra T., Aron, Justin JJ, van der Hooft, Francesco, Russo, Mingxun, Wang, Yasin, El Abiead, Kai, Dührkop, Thapanee, Pruksatrakul, Tomáš, Pluskal, Shane, Farrell, Robin, Schmid, Magdalena, Pöchhacker, Steffen, Heuckeroth, Lana G., Graves, Karoline, Steuer-Lodd, Marcelo, Navarro-Díaz, Shipei, Xing, Filip, Ottosson, Andres, Cumsille, Yunshu, Wang, Giovanni Andrea, Vitale, Martinus, de Kruijff, Daniel, Petras, Andrés M., Caraballo-Rodríguez, Christine, Beemelmanns, Paulo Wender, Portal Gomes, Marquis T., Yazzie, Eftychia E., Kontou, Anastasiia, Kostenko, Berenike C., Wagner, Nathan, Chan, Paolo, Stincone, Christoph, Mayer, Judith, Boldt, Jarmo-Charles, Kalinski, Martin, Hansen, Stilianos, Papadopoulos Lambidis, Jan, Stanstrup, Abzer K., Pakkir Shah, Christian, Geibel, Alexandros, Polyzois, Mirte CM., Kuijpers, Tito, Damiani, Simone, Zuffa, Sibgha, Tayyab, Madeleine, Ernst, Beatriz, Cámara, Axel, Walter, Marie R., Aggerbeck, Simon, Knoblauch, Tilman, Schramm, James, Elofson, Fernanda, de Oliveira, Kevin, Mildau, Carolina, González-Marín   +56 more
core   +1 more source