Results 21 to 30 of about 90,676 (185)

Metabolomics in Drug Target Discovery [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2011
Most diseases result in metabolic changes. In many cases, these changes play a causative role in disease progression. By identifying pathological metabolic changes, metabolomics can point to potential new sites for therapeutic intervention. Particularly promising enzymatic targets are those that carry increased flux in the disease state.
J D, Rabinowitz, J G, Purdy, L, Vastag, T, Shenk, E, Koyuncu   +4 more
openaire   +2 more sources

Targeted Metabolomics Data [PDF]

, 2023
targeted metabolomics analysis of the fetal lungs, in a delayed labor mouse model, steroid receptor coactivator (SRC)1/SRC2 double knockout (dKO) mouse.
Xuesong Sui (15206344)
core   +1 more source

Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry [PDF]

, 2020
Introduction: Standardized commercial kits enable targeted metabolomics analysis and may thus provide an attractive complement to the more explorative approaches.
Khoonsari, PE, Carlsson, H, Kultima, Kim, Emami Khoonsari, Payam,, Emami Khoonsari, Payam, Åkerfeldt, Torbjörn,, Burman, J, Herman, Stephanie,, Akerfeldt, T, Svenningsson, Anders, Abujrais, S, Svenningsson, A,, Abujrais, Sandy, Herman, Stephanie, Burman, Joachim, Burman, Joachim,, Carlsson, Henrik, Abujrais, Sandy,, Carlsson, Henrik,, Svenningsson, Anders,, Kultima, K, Kultima, Kim,, Herman, S, Åkerfeldt, Torbjörn   +23 more
core   +1 more source

Targeted Metabolomics Analysis of Bile Acids in Patients with Idiosyncratic Drug-Induced Liver Injury [PDF]

, 2021
Drug-induced liver injury (DILI) is rare but clinically important due to a high rate of mortality. However, specific biomarkers for diagnosing and predicting the severity and prognosis of DILI are lacking.
Ermei Chen, Fen Zhang, Lanlan Xiao, Qiuhong Liu, Lingjian Zhang, Xiaowei Xu, Zhongyang Xie, Juan Lu, Danhua Zhu, Lanjuan Li   +9 more
core   +1 more source

Metabolomics and human nutrition [PDF]

, 2011
The present report summarises a workshop convened by the UK Food Standards Agency (Agency) on 25 March 2010 to discuss the current Agency's funded research on the use of metabolomics technologies in human nutrition research.
Mathers, John, Sandy Primrose, Kirkpatrick, Verity, Chris Seal, Primrose, Sandy, Beckmann, Manfred, Draper, John, John H. Beattie, Elsom, Rachel, John Draper, Sumanto Haldar, Seal, Chris, Augustin Scalbert, Beattie, John, Jenab, Mazda, Keun, Hector, Hector Keun, Rachel Elsom, Haldar, Sumanto, John K. Lodge, Manfred Beckmann, Scalbert, Augustin, Lodge, John, Verity Kirkpatrick, John C. Mathers, Mazda Jenab   +25 more
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Symposium 2: Modern approaches to nutritional research challenges: Targeted and non-targeted approaches for metabolite profiling in nutritional research. [PDF]

, 2010
The present report discusses targeted and non-targeted approaches to monitor single nutrients and global metabolite profiles in nutritional research. Non- targeted approaches such as metabolomics allow for the global description of metabolites in a ...
Lodge, John K., Lodge, John
core   +1 more source

Comparative analysis of bile metabolic profile in patients with biliary obstruction complicated by Clonorchis sinensis infection

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundClonorchiasis is an important foodborne parasitic disease. However, eggs of Clonorchis sinensis (C. sinensis) cannot be detected in feces during biliary obstruction.
Xueli Zhang, Su Han, Su Han, Xu Jiang, Shanshan Duan, Yannan Gao, Jian Ding, Xiang Li, Beibei Sun, Xinyi Hu, Xiaoli Zhang, Weizhe Zhang   +11 more
doaj   +1 more source

Genetics Meets Metabolomics [PDF]

, 2008
The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the human body.
Wichmann, Heinz-Erich, Elisabeth Altmaier, Weinberger, K.M., Weinberger Klaus M., Gieger, C., Christian Gieger, Illig, Thomas, Karsten Suhre, Meitinger, Thomas, Hrabě de Angelis, M., Mewes, H.-W., Adamski, Jerzy, H-Erich Wichmann, Thomas Illig, Klaus M Weinberger, Martin Hrabé de Angelis, Geistlinger Ludwig, Suhre Karsten, Gieger, Christian, Suhre, K., Weinberger, Klaus M., Kronenberg, Florian, Mewes, Hans-Werner, Gieger Christian, Altmaier, E., Hans-Werner Mewes, Wichmann, H.-E., Adamski Jerzy, Illig, T., Thomas Meitinger, Hrabé de Angelis Martin, Meitinger, T., Mewes Hans-Werner, Geistlinger, Ludwig, Illig Thomas, Ludwig Geistlinger, Geistlinger, L., Kronenberg Florian, Altmaier, Elisabeth, Wichmann H.-Erich, Kronenberg, F., Adamski, J., Hrabé de Angelis, Martin, Florian Kronenberg, Jerzy Adamski, Suhre, Karsten, Altmaier Elisabeth, Meitinger Thomas   +47 more
core   +1 more source

A one-year pilot study comparing direct-infusion high resolution mass spectrometry based untargeted metabolomics to targeted diagnostic screening for inherited metabolic diseases

Frontiers in Molecular Biosciences, 2023
Background: Early diagnosis of inherited metabolic diseases (IMDs) is important because treatment may lead to reduced mortality and improved prognosis. Due to their diversity, it is a challenge to diagnose IMDs in time, effecting an emerging need for a ...
Anke P. Willems, Maria van der Ham, Birgit G. M. Schiebergen-Bronkhorst, Mirjam van Aalderen, Martina M. J. de Barse, Fini E. De Gruyter, Ilja N. van Hoek, Mia L. Pras-Raves, Monique G. M. de Sain-van der Velden, Hubertus C. M. T. Prinsen, Nanda M. Verhoeven-Duif, Judith J. M. Jans   +11 more
doaj   +1 more source

Advance in the Application of Metabonomics in the Field of Food Safety and Quality [PDF]

Shipin Kexue, 2023
Food safety and quality are the basis and prerequisite for ensuring the harmonious and stable development of the modern economy and society. At present, foodborne pathogens, veterinary drug residues, genetically modified foods and adulteration cause or ...
SHEN Yanghong, FANG Jinyu, ZHU Junli, WANG Yanbo
doaj   +1 more source