Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year [PDF]
, 2020 Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production.
Yu Ra Lee +9 more
core +1 more source
Cross-Platform Evaluation of Commercially Targeted and Untargeted Metabolomics Approaches to Optimize the Investigation of Psychiatric Disease [PDF]
, 2021 Metabolomics methods often encounter trade-offs between quantification accuracy and coverage, with truly comprehensive coverage only attainable through a multitude of complementary assays.
Salek, R. +17 more
core +1 more source
Non-Targeted Metabolomic Analysis of the Kombucha Production Process [PDF]
Metabolites, 2022 Kombucha is a traditional fermented beverage obtained from the transformation of sugared black tea by a community of yeasts and bacteria. Kombucha production recently became industrialized, but its quality standards remain poorly defined. Metabolomic analyses were applied using FT-ICR-MS to characterize the impacts of production phases and the type of ...
Tran, Thierry +8 more
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Metabolomics in Corneal Diseases: A Narrative Review from Clinical Aspects [PDF]
, 2023 Corneal pathologies may have subtle manifestations in the initial stages, delaying diagnosis and timely treatment. This can lead to irreversible visual loss.
Jingwen Zhang +7 more
core +1 more source
Statistical Workflow for Feature Selection in Human Metabolomics Data [PDF]
, 2019 High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease.
Henglin, Mir +35 more
core +1 more source
LC-HRMS-Based Non-Targeted Metabolomics for the Assessment of Honey Adulteration with Sugar Syrups: A Preliminary Study [PDF]
, 2022 Honey is a natural product that is in great demand and has a relatively high price, thus making it one of the most common targets of economically motivated adulteration.
Marianna Martinello +9 more
core +1 more source
LC-MS/MS based targeted metabolomics method for analysis of serum and cerebrospinal fluid
Journal of Medical Science, 2019 Introduction. Recent instrumentation and software advancement enabled to develop new, high‑throughput targeted metabolomics methods for in‑depth exploration of metabolome in a quantitative manner. Material and Methods. The presented targeted metabolomics
Szymon Plewa +8 more
doaj +1 more source
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]
, 2013 <p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achcar, Fiona, +23 more
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Targeted and untargeted metabolomic approach for GDM diagnosis
Frontiers in Molecular Biosciences, 2023 Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism. It is also known that fatty acid profile changes in erythrocyte membranes and plasma could be associated with obesity and insulin resistance. These factors can lead to the development of diabetes.
Izabela Burzynska-Pedziwiatr +14 more
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Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis [PDF]
Neurobiology of Aging, 2020 The development of Alzheimer's dementia (AD) accompanies both central and peripheral metabolic disturbance, but the metabolic basis underlying AD and metabolic markers predictive of AD risk remain to be determined. It is also unclear whether the metabolic changes in the peripheral blood and brain are overlapping in relation to AD.
Zhiguang Huo +5 more
openaire +2 more sources