Results 41 to 50 of about 2,519,690 (191)

Metabolic Profiling Identified a Novel Biomarker Panel for Metabolic Syndrome-Positive Hepatocellular Cancer

Frontiers in Endocrinology, 2022
Metabolic syndrome (MetS) is an independent risk factor for hepatocellular cancer (HCC). Currently, there is no highly sensitive and specific biomarkers for HCC surveillance in MetS population.
Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, Hui Wang   +9 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice

Nature Communications
Exercise is usually regarded to have short-term beneficial effects on immune health. Here we show that early-life regular exercise exerts long-term beneficial effects on inflammatory immunity.
Nini Zhang, Xinpei Wang, Mengya Feng, Min Li, Jing Wang, Hongyan Yang, Siyu He, Ziqi Xia, Lei Shang, Xun Jiang, Mao Sun, Yuanming Wu, Chaoxue Ren, Xing Zhang, Jia Li, Feng Gao   +15 more
doaj   +1 more source

Practical and Efficient Synthesis of α-Aminophosphonic Acids Containing 1,2,3,4-Tetrahydroquinoline or 1,2,3,4-Tetrahydroisoquinoline Heterocycles

Molecules, 2016
We report here a practical and efficient synthesis of α-aminophosphonic acid incorporated into 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline heterocycles, which could be considered to be conformationally constrained analogues of ...
Mario Ordóñez, Alicia Arizpe, Fracisco J. Sayago, Ana I. Jiménez, Carlos Cativiela   +4 more
doaj   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

Enantioselective Synthesis of Substituted Pipecolic Acid Derivatives

, 2016
Enantiomerically pure 4-piperidones, prepared by asymmetric [4 + 2] Diels−Alder cycloadditon of chiral 2-aminodienes with imines, have been used as starting materials for the synthesis of several derivatives of pipecolic acid.
Fernando Aznar (2087200), Cristina Ribas (3040539), José Barluenga (268140), Carlos Valdés (2473141)   +3 more
core   +1 more source

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Molecules, 2017
A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references).
Sarah Rioton, Domingo Gomez Pardo, Janine Cossy   +2 more
doaj   +1 more source

The epigenetic landscape of plant defense: Unlocking nature's toolkit for new plant protection

New Plant Protection, EarlyView.
This review examines how epigenetic mechanisms regulate plant immune gene activation, repression, and priming, then links these natural regulatory layers to emerging epigenetic editing, discussing their potential for precise, heritable crop protection and the challenges.
Xuexia Liu, Zhenhui Zhong
wiley   +1 more source

6-Alkynyl- and 6-Aryl-Substituted (R)-Pipecolic Acid Derivatives

, 2013
Sadiq A, Sewald N. 6-Alkynyl- and 6-Aryl-Substituted (R)-Pipecolic Acid Derivatives. Organic Letters. 2013;15(11):2720-2722.(R)-alpha-Aminoadipic acid is a readily available enantiomerically pure starting material for the synthesis of (R)-pipecolic acid ...
Sadiq, Amina, Sewald, Norbert ; https://orcid.org/   +1 more
core   +1 more source

Concise and Straightforward Asymmetric Synthesis of a Cyclic Natural Hydroxy-Amino Acid

Molecules, 2014
An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic acid starting from D-glucoheptono-1, 4-lactone is presented.
Mario J. Simirgiotis, Javier Vallejos, Carlos Areche, Beatriz Sepúlveda   +3 more
doaj   +1 more source