Results 111 to 120 of about 13,466,171 (149)

Antitussive agents as N-methylaspartate antagonists: further studies

Canadian Journal of Physiology and Pharmacology, 1989
The relative potencies of ketamine and the morphinan derivatives dextrorphan, dextromethorphan, and levorphanol as antagonists of the excitatory actions of N-methylaspartate on rat spinal neurones in vivo were examined, both following their microelectrophoretic administration and, with the exception of levorphanol, after intravenous injection. Applied
J, Church, M G, Jones, S N, Davies, D, Lodge   +3 more
openaire   +3 more sources

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Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate

Life Sciences, 1986
The dissociative anaesthetics, phencyclidine and ketamine, block excitation of central neurones by N-methylaspartate. Using the technique of microelectrophoresis on rat spinal neurones in vivo Metaphit, a phencyclidine receptor acylating agent, was tested to see whether it would antagonise this effect of dissociative anaesthetics.
K C Rice, J Church, R A Lessor
exaly   +3 more sources

N-methylaspartate receptors mediate epileptiform activity evoked in some, but not all, conditions in rat neocortical slices

Neuroscience, 1986
Using intracellular recordings from pyramidal neurons in isolated slices of rat cerebral cortex epileptiform discharges evoked (1) in the presence of gamma-aminobutyric acid antagonists, and (2) in the absence of Mg2+ were compared. Depolarization shift responses recorded in the presence of bath applied picrotoxin, or electrophoretically applied ...
A M Thomson, D C West
exaly   +3 more sources

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

Brain Research, 1987
We have examined the effects of ketamine and kynurenate on the initial response and frequency dependent potentiation of response (wind-up) of class 2 neurones of the rat dorsal horn induced by repeated electrical stimulation of their receptive fields. Iontophoretic kynurenate reduced both the initial response and the wind-up.
S N Davies, D Lodge
exaly   +3 more sources

Evidence for a direct action ofN-methylaspartate on non-neuronal cells

Brain Research, 1987
The effects of N-methylaspartate (NMA) on extracellular amino acids and purine catabolites in the hippocampus were studied with brain dialysis in rats with unilateral hippocampal NMA lesions. In the lesioned side, an increased basal output of glutamine was observed while glutamate was significantly decreased.
Anders Lehmann
exaly   +3 more sources

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans [PDF]

Applied Microbiology and Biotechnology, 2011
Methylaspartate ammonia lyase (MAL; EC 4.3.1.2) catalyzes the reversible addition of ammonia to mesaconate to give (2S,3S)-3-methylaspartate and (2S,3R)-3-methylaspartate as products.
Frank Dekker, Dick Janssen, Wim Quax
exaly   +4 more sources

Succinyl-CoA:Mesaconate CoA-Transferase and Mesaconyl-CoA Hydratase, Enzymes of the Methylaspartate Cycle in Haloarcula hispanica [PDF]

Frontiers in Microbiology, 2017
Growth on acetate or other acetyl-CoA-generating substrates as a sole source of carbon requires an anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks.
Ivan Berg, Peter Schönheit, Ulrike Johnsen   +2 more
exaly   +2 more sources

Kinetic Resolution and Stereoselective Synthesis of 3‐Substituted Aspartic Acids by Using Engineered Methylaspartate Ammonia Lyases

Chemistry - A European Journal, 2013
Kinetic resolution and asymmetric synthesis of various valuable 3-substituted aspartic acids, which were obtained in fair to good yields with diastereomeric ratio values of up to >98:2 and enantiomeric excess values of up to >99 %, by using engineered ...
Dick Janssen, Wim Quax, Gerrit Poelarends   +2 more
exaly   +2 more sources

The roles of active site residues in the catalytic mechanism of methylaspartate ammonia‐lyase [PDF]

FEBS Open Bio, 2013
Methylaspartate ammonia-lyase (MAL; EC 4.3.1.2) catalyzes the reversible addition of ammonia to mesaconate to yield l-threo-(2S,3S)-3-methylaspartate and l-erythro-(2S,3R)-3-methylaspartate as products.
Raj, Hans, Gerrit J. Poelarends, Hans Raj, Poelarends, Gerrit J; id_orcid, Poelarends, Gerrit J., Poelarends, Gerrit J   +5 more
exaly   +3 more sources