Results 121 to 130 of about 13,466,171 (149)
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General Pharmacology: The Vascular System, 1990
1. Drugs with phencyclidine (PCP)-like activity in behavioural discrimination and [3H]PCP binding studies share anticonvulsant properties. 2. We have compared the rank order potency of a series of PCP-like compounds as N-methylaspartate (NMA) antagonists, determined from previously published studies from our laboratory, with their rank order ...
J, Church, D, Lodge
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1. Drugs with phencyclidine (PCP)-like activity in behavioural discrimination and [3H]PCP binding studies share anticonvulsant properties. 2. We have compared the rank order potency of a series of PCP-like compounds as N-methylaspartate (NMA) antagonists, determined from previously published studies from our laboratory, with their rank order ...
J, Church, D, Lodge
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N-methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat
Brain Research, 1986The ability of the excitotoxin, N-methyl-D,L-aspartic acid (NMA), to destroy basal forebrain cholinergic (BFC) neurons was evaluated. NMA (100 nmol) was directly injected into the peripallidum, a region containing a proportionately large number of cortically-projecting BFC neurons. Cholineacetyltransferase (ChAT) activity 10 days later was markedly and
G R, Stewart +4 more
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Cyclazocine and pentazocine as N-methylaspartate antagonists on cat and rat spinal neurons in vivo.
The Journal of Pharmacology and Experimental Therapeutics, 1990The effects of the racemic mixtures and separated enantiomers of cyclazocine and pentazocine were examined on the responses of spinal neurons to excitatory amino acid analogs and acetylcholine in pentobarbital-anesthetized cats and rats. Each compound was administered both by microelectrophoresis and by i.v. injection. The racemic mixture and separated
J, Church, D, Lodge
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European Journal of Pharmacology, 1983
In pentobarbitone-anaesthetised cats and rats effects of stereoisomers of two methylated congeners of phencyclidine, GK4 and GK5, and (+)- and (-)-PCMP, were examined on the excitation of spinal neurones by electrophoretically administered excitatory amino acids and acetylcholine.
S C, Berry +3 more
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In pentobarbitone-anaesthetised cats and rats effects of stereoisomers of two methylated congeners of phencyclidine, GK4 and GK5, and (+)- and (-)-PCMP, were examined on the excitation of spinal neurones by electrophoretically administered excitatory amino acids and acetylcholine.
S C, Berry +3 more
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Neurochemical Research, 2002
Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in NAA, with no further change in PCr ...
N M, Thatcher +7 more
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Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in NAA, with no further change in PCr ...
N M, Thatcher +7 more
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An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?
Nature, 1985It has been proposed that three major receptor subtypes subserve the putative transmitter role of glutamate and aspartate in the mammalian central nervous system. One subtype is classified by the specific agonist N-methylaspartate (NMA) and the specific antagonist 4-amino-2-phosphonovaleric acid.
A M, Thomson, D C, West, D, Lodge
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Neuropharmacology, 1984
The selective N-methylaspartate (NMA) receptor antagonist 2-amino-5-phosphonopentanoate (AP5) has been applied to the lumbar region of the spinal cord in conscious rats through chronically implanted intrathecal cannulae. Administration of AP5 was compared with administration of 2-amino-4-phosphonobutyrate (AP4), morphine and control injections ...
P M, Cahusac +4 more
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The selective N-methylaspartate (NMA) receptor antagonist 2-amino-5-phosphonopentanoate (AP5) has been applied to the lumbar region of the spinal cord in conscious rats through chronically implanted intrathecal cannulae. Administration of AP5 was compared with administration of 2-amino-4-phosphonobutyrate (AP4), morphine and control injections ...
P M, Cahusac +4 more
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Stereotactic and Functional Neurosurgery, 1985
It has been shown that N-methylaspartate (NMA), kainic acid (KA), and quisqualic acid (QA) can produce preferential neuronal damage in various parts of the striatum, hippocampus, and thalamus with relative sparing of axons in transit. Thus far, the evidence that axons in transit escape destruction has been based largely on histological observations. To
M, Pisharodi, H J, Nauta
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It has been shown that N-methylaspartate (NMA), kainic acid (KA), and quisqualic acid (QA) can produce preferential neuronal damage in various parts of the striatum, hippocampus, and thalamus with relative sparing of axons in transit. Thus far, the evidence that axons in transit escape destruction has been based largely on histological observations. To
M, Pisharodi, H J, Nauta
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Brain Research, 1981
Here we report that the D-isomers of 2-amino-5-phosphonovalerate (D-APV) and alpha-amino-adipate (D-alpha AA) protect arcuate hypothalamic neurons from the potent excitotoxic activity of N-methylaspartate (NMA). Consistent with evidence that APV is much more powerful than alpha AA in antagonizing the neuroexcitatory activity of NMA, we found D-APV ...
J W, Olney +3 more
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Here we report that the D-isomers of 2-amino-5-phosphonovalerate (D-APV) and alpha-amino-adipate (D-alpha AA) protect arcuate hypothalamic neurons from the potent excitotoxic activity of N-methylaspartate (NMA). Consistent with evidence that APV is much more powerful than alpha AA in antagonizing the neuroexcitatory activity of NMA, we found D-APV ...
J W, Olney +3 more
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ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Klaus Burger, Jan Spengler
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Klaus Burger, Jan Spengler
openaire +1 more source