Results 91 to 100 of about 17,313 (241)

N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

Nature Communications, 2020
Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects ...
Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin, Hongsheng Wang   +7 more
doaj   +1 more source

Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability.
Tamar Woudenberg, M. Leontien van der Bent, Veerle Kremer, Ingeborg S. E. Waas, Mat J. A. P. Daemen, Reinier A. Boon, Paul H. A. Quax, A. Yaël Nossent   +7 more
wiley   +1 more source

METTL16 and YTHDC1 Regulate Spermatogonial Differentiation via m6A

Cell Proliferation, EarlyView.
The deletion of either Mettl16 or Ythdc1 with Stra8‐Cre disrupted the gene expression related to chromosome organisation and segregation, resulting in aberrant differentiation of spermatogonia and male infertility. ABSTRACT Spermatogenesis is a highly unique and intricate process, finely regulated at multiple levels, including post‐transcriptional ...
Xueying Gu, Xinyuan Dai, Haifeng Sun, Yilong Lian, Xingxu Huang, Bin Shen, Pengfei Zhang   +6 more
wiley   +1 more source

YTHDC1 Modulates the Osteogenic Capacity of hPDLSCs via Wnt/β‐Catenin Signalling Pathway for the Treatment of Bone Defects in Osteoporosis Rats

Cell Proliferation, EarlyView.
In this study, human periodontal ligament stem cells (hPDLSCs) were successfully isolated and cultivated from the periodontal ligament tissues of healthy premolar teeth. Our in vivo experiments demonstrated that YTHDC1 augmented the osteogenic differentiation capacity of these cells via the Wnt/β‐catenin signalling pathway.
Dan Tan, Qilin Li, Zhenzhen Chen, Hongbing Zhang, Pengcheng Rao, Jingxiang Li, Qianke Tao, Jingang Xiao, Jinlin Song   +8 more
wiley   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj  

Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures [PDF]

, 1976
Robert M. Krug, M A Morgan, Aaron J. Shatkin   +2 more
openalex   +1 more source

Accelerating Bone Healing With METTL3 Overexpressed Adipose‐Derived Stem Cells in Osteoporotic Rats

Cell Proliferation, EarlyView.
METTL3 promotes osteogenic differentiation of osteoporotic adipose‐derived stem cells and accelerates the repair of cranial defect areas in osteoporotic rats by activating the Wnt signalling pathway. ABSTRACT The treatment of postmenopausal osteoporosis (OP) presents a multifaceted challenge.
Hui Tang, Zhenzhen Chen, Lu Zeng, Yuping Xie, Daowen Luo, Shuanglin Peng, Fangzhi Lou, Tianli Wu, Jingang Xiao   +8 more
wiley   +1 more source

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase [PDF]

, 2014
Xiaoli Ping, Baofa Sun, Lu Wang, Wen Xiao, Xin Yang, Wenjia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yusheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiaomin Lou, Xi Liu, Jun Huang, Weiping Yuan, Xiaofan Zhu, Tao Cheng, Yongliang Zhao, Xinquan Wang, Jannie M. Rendtlew Danielsen, Feng Liu, Yun‐Gui Yang   +24 more
openalex   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding [PDF]

, 2015
Katherine I. Zhou, Marc Parisien, Qing Dai, Nian Liu, Luda Diatchenko, Joseph R. Sachleben, Tao Pan   +6 more
openalex   +1 more source