Results 81 to 90 of about 53,902 (279)

Global profiling of N6‐methyladenosine methylation in maize callus induction

The Plant Genome, 2020
Callus induction is a dedifferentiation process that accompanies a cell fate transition, and epigenetic regulation plays a crucial role in the process.
Xuemei Du, Ting Fang, Yan Liu, Meng Wang, Maosen Zang, Liying Huang, Sihan Zhen, Jie Zhang, Zichen Shi, Guoying Wang, Junjie Fu, Yunjun Liu   +11 more
doaj   +1 more source

DataSheet_1_Identification and Validation of N6-Methyladenosine-Related Biomarkers for Bladder Cancer: Implications for Immunotherapy.pdf

, 2022
N6-methyladenosine (m6A) has emerged as one of the most important modifications of RNA. Based on the expression of 23 different modes of m6A regulatory factors, we identified three different m6A modification patterns in bladder cancer. The effects of the
Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Dongyong Shan (6456368), Xingyu Chen (1938484), Ke Cao (569991)   +5 more
core   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4

Nature Communications, 2022
Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.
Qiang Luo, Jiezhen Mo, Hao Chen, Zetao Hu, Baihui Wang, Jiabing Wu, Ziyu Liang, Wenhao Xie, Kangxi Du, Maolin Peng, Yingping Li, Tianyang Li, Yangyi Zhang, Xiaoyan Shi, Wen-Hui Shen, Yang Shi, Aiwu Dong, Hailin Wang, Jinbiao Ma   +18 more
doaj   +1 more source

Data_Sheet_1_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj   +1 more source

N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor' LOXL3

Clinical and Translational Medicine, 2022
Background A number of studies have demonstrated that N6‐methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma.
Hao‐ze Shi, Jing‐shu Xiong, Lu Gan, Ying Zhang, Cong‐cong Zhang, Ying‐qi Kong, Qiu‐ju Miao, Cui‐cui Tian, Rong Li, Jin‐quan Liu, Er‐jia Zhang, Wen‐bo Bu, Yan Wang, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +15 more
doaj   +1 more source

Data_Sheet_9_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.zip

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source