Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Comprehensive analysis of N6-methyladenosine regulators with the tumor immune landscape and correlation between the insulin-like growth factor 2 mRNA-binding protein 3 and programmed death ligand 1 in bladder cancer [PDF]
, 2021 Jianfeng Cui +7 more
openalex +1 more source
1H NMR metabolomic study of auxotrophic starvation in yeast using Multivariate Curve Resolution-Alternating Least Squares for Pathway Analysis [PDF]
, 2016 Disruption of specific metabolic pathways constitutes the mode of action of many known toxicants and it is responsible for the adverse phenotypes associated to human genetic defects.
Alfonso, Ignacio +3 more
core +1 more source
Nature CommunicationsThere is strong evidence that obesity is a risk factor for poor semen quality. However, the effects of multigenerational paternal obesity on the susceptibility to cadmium (a reproductive toxicant)-induced spermatogenesis disorders in offspring remain ...
Yong-Wei Xiong +18 more
doaj +1 more source
Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing
Nature Communications, 2023 Direct RNA sequencing using nanopore platform can be used to detect N6-methyladenosine (m6A) modifications on mRNAs. Here the authors systematically compare tools used for m6A detection from nanopore direct sequencing.
Zhen-Dong Zhong +11 more
doaj +1 more source
WITHDRAWN: N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer Progression via IGF2BP2 [PDF]
, 2021 openalex +1 more source
Human ALKBH4 Interacts with Proteins Associated with Transcription [PDF]
, 2015 The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs (ALKBH1-8 and FTO). ALKBH2 and ALKBH3
Bjørnstad, Linn +5 more
core +3 more sources
Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA
Angewandte Chemie, EarlyView.Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl +1 more
wiley +1 more source
The crosstalk between N6‐methyladenosine readers and neuroblastoma
Clinical and Translational DiscoveryBackground Neuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications. Methods This review explores the role of N6‐methyladenosine (m6A) modifications and their readers in NB progression.
Liping Chen, Jing He, Zhenjian Zhuo
doaj +1 more source
Neural Regeneration ResearchThe neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury. The post-transcriptional modification of N6-methyladenosine is ubiquitous in the immune response of the ...
Xiangrong Chen +6 more
doaj +1 more source