RNA N6‐methyladenosine connects YTHDF3 and LOXL3 to promote melanoma metastasis
Clinical and Translational Discovery, 2022 N6‐methyladenosine (m6A) modifications of RNAs are associated with diverse biological processes in normal and cancer cells. In melanoma cancers, mutations in genes that function in the writing or erasure of RNA m6A have been shown to affect cancer ...
Mamta B Nirmal, Tommy V. Vo
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993 Epidermis-intrinsic N6-methyladenosine modification dampens skin inflammation [PDF]
, 2023 Longfei Cui +5 more
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Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Angewandte Chemie International Edition, EarlyView.Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation [PDF]
Nature Chemical Biology, 2018 N6-Methyladenosine (m6A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6A modifications have been extensively studied and shown to play critical roles in many cellular processes, the identity of m6A methyltransferases for rRNAs and the function of rRNA m6A ...
Honghui Ma +15 more
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tRNA Thiolation Links Translation to Stress Responses in Saccharomyces cerevisiae [PDF]
, 2014 Although tRNA modifications have been well catalogued, the precise functions of many modifications and their roles in mediating gene expression are still being elucidated.
Damon, Jadyn Rose +2 more
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Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication
VirusesEnteroviruses such as coxsackievirus B3 are identified as a common cause of viral myocarditis, but the potential mechanism of its replication and pathogenesis are largely unknown. The genomes of a variety of viruses contain N6-methyladenosine (m6A), which plays important roles in virus replication.
Hainian Zhao +9 more
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The biological function of demethylase ALKBH1 and its role in human diseases
HeliyonAlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong +4 more
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FTO promotes the progression of cervical cancer by regulating the N6‐methyladenosine modification of ZEB1 and Myc [PDF]
, 2023 Aihong Wang +5 more
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Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]
, 2019 Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E. +7 more
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