Results 91 to 100 of about 20,108 (223)

WTAP‐Mediated m6A Modification of TXNDC5 mRNA Promotes Cervical Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT WT1‐associated protein (WTAP), a core component of the methyltransferase complex, is involved in various tumor pathological processes, but its specific mechanism in cervical cancer (CC) remains unclear. This study, based on single‐cell transcriptomic data (including 3 CC and 2 normal tissues), constructed a CC microenvironment cell atlas ...
Ling Chen, Nuo‐Xin Hu, Zhao‐Ying Chen, Ke‐An Zhu, Wei Huang   +4 more
wiley   +1 more source

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

Acta Pharmaceutica Sinica B, 2018
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan   +4 more
doaj   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

Regulatory effect of N6-methyladenosine on tumor angiogenesis

Frontiers in Immunology
Previous studies have demonstrated that genetic alterations governing epigenetic processes frequently drive tumor development and that modifications in RNA may contribute to these alterations. In the 1970s, researchers discovered that N6-methyladenosine (m6A) is the most prevalent form of RNA modification in advanced eukaryotic messenger RNA (mRNA) and
YuYan, Enwu Yuan
openaire   +3 more sources

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

YTHDF3 promotes melanoma metastasis by reading N6‐methyladenosine

Clinical and Translational Discovery, 2022
Ivan Yu Cheng, Chun‐Ming Wong
doaj   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source