Results 121 to 130 of about 28,700 (263)

Deciphering epigenetic regulation in postmenopausal osteoporosis: Current and future perspectives

VIEW, EarlyView.
In this perspective, the significant roles of microRNAs, long noncoding RNAs and circular RNAs in postmenopausal osteoporosis are thoroughly expounded. The advantages and limitations of typical noncoding RNAs as diagnostic biomarkers and therapeutic targets are summarized and discussed.
Xiumei Tang, Meiru Chen, Guixuan Xu, Yuan Li, Sen Guo, Yufeng Huang, Zhaoliang Hou, Xiaoling Hou, Zhijian Wei, Wenzhao Wang, Bing Ning   +10 more
wiley   +1 more source

The m6A Demethylase Fto Enhances Susceptibility to Atrial Fibrillation by Demethylating Kcne1 in Aging Mice

Aging Cell, EarlyView.
Aging‐induced accumulation of PGE2 in cardiomyocytes blocks the degradation of Fto. Elevation of Fto in the atria represses m6A methylation of Kcnel which, in turn, leads to the reduction of Kcnel mRNA and protein. Reduced Kcnel enhances IKs currents and thereby shortens APD in atrial cardiomyocytes and increases AF inducibility.
Ruopeng Tan, Yuanjun Sun, Mengyang Yuan, Lin Wang, Xinyu Yang, Genlong Xue, Guiwen Xu, Yang Liu, Xiaomeng Yin   +8 more
wiley   +1 more source

Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation

, 2023
Hannah Petraitis Kuschman, Marianne B. Palczewski, Brian M. Hoffman, Mary Menhart, Xiaowei Wang, Sharon A. Glynn, Abul B.M.M.K. Islam, Elizaveta V. Benevolenskaya, Douglas D. Thomas   +8 more
openalex   +1 more source

N6‐Methyladenosine‐Modified circNEK11 Promotes Hepatocellular Carcinoma Progression via the miR‐1236‐3p/GPX2 Axis

Cancer Science, EarlyView.
circNEK11 is overexpressed in human HCC tissues, especially in recurrent tissues, and promotes the oncogenic functions of HCC cells. circNEK11 interacted with miR‐1236‐3p to stimulate GPX2 expression. Our findings highlight the potential of circNEK11 as a biomarker for HCC diagnosis and suggest that targeting circNEK11 may be an effective strategy for ...
Qian Li, Xu Huang, Yan Tong, Caiyu Yong, Minghui Song, Cunjie Chang, Heng Dong, Fangtian Bu, Shuanghong Yan, Jie Ying, Jianxiang Chen   +10 more
wiley   +1 more source

Nanopore direct RNA sequencing maps an Arabidopsis N6 methyladenosine epitranscriptome [PDF]

, 2019
Matthew T Parker, Katarzyna Knop, Anna V. Sherwood, Nick Schurch, Katarzyna Mackinnon, Peter Gould, Anthony Hall, Geoffrey J. Barton, Gordon G. Simpson   +8 more
openalex   +1 more source

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4‐Mediated Immune Evasion in Acute Monocytic Leukaemia

Cell Proliferation, EarlyView.
Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang, Xiang Luo, Mengyu Zhang, Le Jin, Wenxin Sun, Peihan Chen, Xiuli Hong, Chenyu Xu, Meizhi Jiang, Die Hu, Bin Zhang, Shengwei Hu, Chuanjiang Yang, Rui Gao, Jinzhang Zeng, Quanyi Lu, Qiang Luo, Jun Wu, Siming Chen   +18 more
wiley   +1 more source

YTHDF3 promotes melanoma metastasis by reading N6‐methyladenosine

Clinical and Translational Discovery, 2022
Ivan Yu Cheng, Chun‐Ming Wong
doaj   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

CRISPR/dCas13(Rx) Derived RNA N6‐methyladenosine (m6A) Dynamic Modification in Plant

Advanced Science
N6‐methyladenosine (m6A) is the most prevalent internal modification of mRNA and plays an important role in regulating plant growth. However, there is still a lack of effective tools to precisely modify m6A sites of individual transcripts in plants. Here,
Lu Yu, Muna Alariqi, Baoqi Li, Amjad Hussain, Huifang Zhou, Qiongqiong Wang, Fuqiu Wang, Guanying Wang, Xiangqian Zhu, Fengjiao Hui, Xiyan Yang, Xinhui Nie, Xianlong Zhang, Shuangxia Jin   +13 more
doaj   +1 more source

N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors [PDF]

, 2022
Huanan Li, Yang Guo, Wenbao Qi, Ming Liao   +3 more
openalex   +1 more source