Results 121 to 130 of about 17,313 (241)

N6-methyladenosine (m6A) RNA modification in cancer stem cells [PDF]

, 2020
Zhonghua Ma, Jiafu Ji
openalex   +1 more source

NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The N‐acetyltransferase‐10 (NAT10)‐mediated mRNA N4‐acetylcytidine modification enhances the stability of CXCL2 and KLF5 mRNA. Then, secreted CXCL2 promotes M2 macrophage polarization and oncostatin M secretion, activating NAT10 expression via STAT3 signaling.
Chen Chen, Zhangding Wang, Qingfeng Lin, Mengmeng Li, Lei Xu, Yao Fu, Xiaoya Zhao, Zhuang Ma, Jiawen Xu, Shimeng Zhou, Mingyue Zhang, Yun Qian, Linsen Bao, Bo Wang, Meng Wang, Qingqing Ding, Qiang Wang, Shouyu Wang   +17 more
wiley   +1 more source

FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis

Experimental and Molecular Medicine
N6-methyladenosine (m6A) modification is one of the most prevalent forms of epigenetic modification and plays an important role in the development of degenerative diseases such as osteoarthritis (OA).
Hongyi Zhou, Ziang Xie, Yu Qian, Weiyu Ni, Lei Cui, Xiangqian Fang, Shuanglin Wan, Xiangde Zhao, An Qin, Shunwu Fan, Yizheng Wu   +10 more
doaj   +1 more source

Regulation of Viral Infection by the RNA Modification N6-Methyladenosine [PDF]

, 2019
Graham D. Williams, Nandan S. Gokhale, Stacy M. Horner   +2 more
openalex   +1 more source

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer [PDF]

, 2020
Jiangfeng Li, Haiyun Xie, Yufan Ying, Hong Chen, Huaqing Yan, Liujia He, Mingjie Xu, Xin Xu, Zhen Liang, Ben Liu, Xiao Wang, Xiangyi Zheng, Liping Xie   +12 more
openalex   +1 more source

CircDNA2‐Educated YTHDF2 Phase Separation Promotes PM2.5‐Induced Malignant Transformation Through the Blunting of GADD45A Expression

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study unveiled the mechanism by which circDNA2‐educated YTHDF2 phase separation promotes PM2.5‐induced malignant transformation in HBE cells by blunting GADD45A expression, providing definitive evidence for the first time that LLPS is involved in the induction of tumorigenesis by particulate pollutants. Moreover, the clinical value of circDNA2 and
Jie Xu, Zhi Ling, Lijia Yin, Duo Xu, Shenshen Wu, Rui Chen   +5 more
wiley   +1 more source

Connecting N6‐methyladenosine modification to ferroptosis resistance in hepatoblastoma

Clinical and Translational Medicine, 2022
Wan‐Xin Peng, Yin‐Yuan Mo
doaj   +1 more source

N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling [PDF]

, 2019
Abhirami Visvanathan, Vikas Patil, Shibla Abdulla, Jörg D. Hoheisel, Kumaravel Somasundaram   +4 more
openalex   +1 more source

N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1–Regulated Astrocyte Dysfunction and Depressive-like Behaviors [PDF]

, 2020
Rongrong Huang, Yuan Zhang, Ying Bai, Bing Han, Minzi Ju, Biling Chen, Li Yang, Yu Wang, Hongxing Zhang, Haisan Zhang, Chunming Xie, Zhijun Zhang, Honghong Yao   +12 more
openalex   +1 more source

N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The long non‐coding RNA (lncRNA) CD2BP2‐DT is upregulated in breast cancer and correlates with poor patient prognosis. Mechanistically, CD2BP2‐DT drives YBX1 phase separation to stabilize CDK1 and promote breast cancer progression. Moreover, NAT10‐mediated N4‐acetylcytosine (ac4C) modification further enhances CD2BP2‐DT expression.
Hongyu Wang, Bozhi Zhao, Jiayu Zhang, Qunyu Hu, Linlin Zhou, Yinghui Zhang, Yixin Cai, Yuansong Qu, Tao Jiang, Dongwei Zhang   +9 more
wiley   +1 more source