Results 141 to 150 of about 17,313 (241)

Upregulated N6-Methyladenosine RNA in Peripheral Blood: Potential Diagnostic Biomarker for Breast Cancer [PDF]

, 2020
Xiao Han, Xiaobo Fan, Rui Zhang, Guoqiu Wu   +3 more
openalex   +1 more source

NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
NSUN2 is upregulated in CRC and associated with poor prognosis of CRC patients. NSUN2 promotes CRC malignancy independently of its m5C‐enzymatic activity, a mechanism that has not been previously reported. The non‐m5C carcinogenic roles of NSUN2 may be mediated through interactions with CUL4B, thereby activating the ErbB‐STAT3 signalling pathway. NSUN2‐
Yuanbo Hu, Chenbin Chen, Kezhi Lin, Xinya Tong, Tingting Huang, Tianle Qiu, Xietao Chen, Jun Xu, Wangkai Xie, Xiangwei Sun, Shiyu Feng, Mingdong Lu, Zhiguang Zhao, Xiaodong Chen, Xiangyang Xue, Xian Shen   +15 more
wiley   +1 more source

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

Acta Pharmaceutica Sinica B, 2018
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan   +4 more
doaj  

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

, 2017
Ian A. Roundtree, Guan‐Zheng Luo, Zijie Zhang, Xiao Wang, Tao Zhou, Yiquang Cui, Jiahao Sha, Xingxu Huang, Laura Guerrero, Phil Xie, Emily He, Bin Shen, Chuan He   +12 more
openalex   +1 more source

A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions [PDF]

, 2020
Brandon Gheller, Jamie Blum, Ern Hwei Hannah Fong, Olga Malysheva, Benjamin D. Cosgrove, Anna Thalacker‐Mercer   +5 more
openalex   +1 more source

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer [PDF]

, 2021
Senxu Lu, Li Han, Xiao Hu, Tong Sun, Dong-ping Xu, Yalun Li, Qiuchen Chen, Weifan Yao, Miao He, Zhenning Wang, Huizhe Wu, Minjie Wei   +11 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Methyltransferase‐like 3‐mediated N6‐methyladenosine modification of miR‐7212‐5p drives osteoblast differentiation and fracture healing [PDF]

, 2020
Bobin Mi, Yuan Xiong, Chenchen Yan, Lang Chen, Hang Xue, Adriana C. Panayi, Liangcong Hu, Yiqiang Hu, Wu Zhou, Faqi Cao, Guohui Liu   +10 more
openalex   +1 more source

Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway

iMeta, Volume 4, Issue 2, April 2025.
Preconception administration of antibiotics to female mice reduces the abundance of Limosilactobacillus reuteri in the maternal gut microbiota during pregnancy, subsequently affecting propionate levels. Decreased propionate levels downregulated the expression of Gdnf/Ret/Sox10 mediated by GPR41, leading to abnormal development of the enteric nervous ...
Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan   +10 more
wiley   +1 more source

Identification of an N6-methyladenosine (m6A)-related signature associated with clinical prognosis, immune response, and chemotherapy in primary glioblastomas [PDF]

, 2021
Zhiqiang Cai, Jianbo Zhang, Ziying Liu, Jiahao Su, Jing Xu, Zhenjun Li, Hongliang Meng, Heng Zhang, Minjie Huang, Donghai Zhao, Chuanzhi Duan, Xuying He   +11 more
openalex   +1 more source