Results 231 to 240 of about 17,313 (241)
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N6-methyladenosine–encoded epitranscriptomics
Nature Structural & Molecular Biology, 2016N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian
Nian Liu, Tao Pan
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N6-Methyladenosine Methylation of mRNA in Cell Senescence
Cellular and Molecular Neurobiology, 2021Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs, long non-coding RNAs, and RNA-binding proteins.
Lin Zhang, Jian Xia
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The role of N6-methyladenosine mRNA in the tumor microenvironment
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021In recent years, the most widely distributed eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A), has received a large amount of interest, in part due to the development and advances of high-throughput RNA sequencing. The effects of m6A mRNA on tumor progression have been the most widely studied, and large amounts of conflicting data
Shengjun Wang, Min Li, Xuan Zha
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The role of N6-methyladenosine (m6A) in eye diseases
Molecular Biology Reports, 2021N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
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N6-methyladenosine in hematological malignancies: a concise review
Current Opinion in Hematology, 2022Purpose of reviewHematological malignancies are a kind of systemic cancers mostly related to abnormal differentiation of blood stem cells. Because of the poor prognosis, chemotherapy resistance and common recurrence, new mechanisms and treatment therapies are looking forward to be discovered.Recent findingsOver the years, epigenetic abnormalities have ...
Wan-Jie, Wang, Ting-Ting, Xu, Jing, Bao
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The momentous role of N6‐methyladenosine in lung cancer
Journal of Cellular Physiology, 2020AbstractLung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNA in eukaryotes ...
Ruiyao Xu +7 more
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The N6-methyladenosine modification in pathologic angiogenesis
Life SciencesThe vascular system is a vital circulatory network in the human body that plays a critical role in almost all physiological processes. The production of blood vessels in the body is a significant area of interest for researchers seeking to improve their understanding of vascular function and maintain normal vascular operation.
Bin, Li +4 more
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The Functions of N6-Methyladenosine in Nuclear RNAs
Biochemistry (Moscow)N6-methyladenosine (m6A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m6A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m6A-related studies have been focused on the cytoplasmic functions of this ...
Nadezhda A, Zhigalova +3 more
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N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Molecular Neurobiology, 2023Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occurs during growing development and senescence. N6-methyladenosine (m6A), as the most common internal modification of eukaryotic mRNA, fine-tunes gene expression by regulating many aspects of mRNA metabolism, such as splicing ...
Lin Zhang, Jian Xia
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Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Xian Sheng Zhang +2 more
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