Results 221 to 230 of about 46,730 (259)
The functions of N6-methyladenosine modification in lncRNAs
Genes and Diseases, 2020 Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA.
Rong-Zhang He
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
N6-methyladenosine and Neurological Diseases
Molecular Neurobiology, 2022N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the adenosine N6 position and is the most common chemical epigenetic modification among mRNA post-transcriptional modifications, including methylation, demethylation, and recognition.
Nan Zhang +4 more
openaire +2 more sources
The evolution of N6-methyladenosine regulators in plants
Methods, 2022As a reversible modification, N6-methyladenosine (m6A) plays key roles in series of biological processes. Although it has been found that m6A modification is regulated by writers, erasers and readers, their evolutionary processes are still not clearly and systematically described. In the present work, we identified 1592 m6A modification regulators from
Meng, Wu +6 more
openaire +2 more sources
N6-Methyladenosine Modifications in Pulmonary Hypertension
Pharmacology, 2023<b><i>Background:</i></b> The most prevalent kind of RNA methylation modification existing in eukaryotes is N6-methyladenosine (m6A), which is a reversible type of posttranscriptional modification. <b><i>Summary:</i></b> Many studies have reported that m6A participates in cell differentiation, self ...
Yu, Xia +6 more
openaire +2 more sources
N6-Methyladenosine in the Heart
2021Similar to DNA modifications, an epitranscriptome of mRNA modifications emerged over the last few years in the cardiovascular system. Specifically, the discovery of the N6-methyladenosine (m6A) as reversible post-transcriptional modification in mRNAs raised recent interest in those modifications in cardiomyocytes and their role in diseased hearts.
Vivien Kmietczyk +2 more
openaire +1 more source
N6‐methyladenosine (m6A) Modification in Preeclampsia
Reproductive Sciences, 2023Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang +6 more
openaire +2 more sources
N6-methyladenosine–encoded epitranscriptomics
Nature Structural & Molecular Biology, 2016N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian
Nian, Liu, Tao, Pan
openaire +2 more sources
N6-Methyladenosine Methylation of mRNA in Cell Senescence
Cellular and Molecular Neurobiology, 2021Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs, long non-coding RNAs, and RNA-binding proteins.
Lin Zhang, Jian Xia
openaire +2 more sources
N6-methyladenosine in hematological malignancies: a concise review
Current Opinion in Hematology, 2022Purpose of review Hematological malignancies are a kind of systemic cancers mostly related to abnormal differentiation of blood stem cells. Because of the poor prognosis, chemotherapy resistance and common recurrence, new mechanisms and treatment therapies are looking forward to be discovered ...
Wan-Jie, Wang, Ting-Ting, Xu, Jing, Bao
openaire +2 more sources
RNA N6‐methyladenosine in nonocular and ocular disease
Journal of Cellular Physiology, 2021AbstractN6‐methyladenosine (m6A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in eukaryotic messenger RNA (mRNAs). m6A modification exists in both coding mRNA and noncoding RNAs, and its functions are controlled by methyltransferase, demethylase, and m6A reading proteins.
Nan Wang +5 more
openaire +2 more sources