N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Molecular Neurobiology, 2023Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occurs during growing development and senescence. N6-methyladenosine (m6A), as the most common internal modification of eukaryotic mRNA, fine-tunes gene expression by regulating many aspects of mRNA metabolism, such as splicing ...
Lin Zhang, Jian Xia
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Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
Molecular NeurobiologyN6-methyladenosine (m6A) is one of the most common post-transcriptional RNA modifications, which plays a critical role in various bioprocesses such as immunological processes, stress response, cell self-renewal, and proliferation. The abnormal expression of m6A-related proteins may occur in the central nervous system, affecting neurogenesis, synapse ...
Zhuohang, Xian +5 more
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The role of N6-methyladenosine (m6A) modification in plants
Theoretical and Applied GeneticsN6-methyladenosine (m6A) modification is the most prevalent chemical modification identified in eukaryotic mRNA molecules, playing a pivotal role in plant growth, development, and responses to both biotic and abiotic stresses. m6A modification is co-regulated by methyltransferases and demethylases, with recognition proteins specifically binding to m6A ...
Cui-Xian Qin +9 more
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N6-methyladenosine regulators in inflammatory bowel disease
Biochemical and Biophysical Research CommunicationsInflammatory bowel disease (IBD) is a class of recurrent chronic intestinal inflammatory diseases, including Crohn's disease and ulcerative colitis. With the development of industrialization, the incidence of IBD is on the rise and the affected population tends to be younger.
Yao Xiao, Lijing Zhu, Ran Yu, Rong Sun
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A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease
Cell Metabolism, 2021Mohammed Kanchwala +2 more
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N6-methyladenosine-mediated gene regulation and therapeutic implications
Trends in Molecular Medicine, 2023Jianhua Yu, Ping Yi, Yujiao Liu
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Identification and characterization of N6‐methyladenosine modification of circRNAs in glioblastoma
Journal of Cellular and Molecular Medicine, 2021Fulin Liu, Hong Wang, Xiuchao Geng
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Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration
Cells, 2021Xuekun Li, Liqi Shu, Xuejun Cheng
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N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand
Molecular Cell, 2021Junken Aoki +2 more
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Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
Cell Reports, 2021Alexa Mcintyre +2 more
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