Results 191 to 200 of about 20,108 (223)
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N6-methyladenosine in hematological malignancies: a concise review
Current Opinion in Hematology, 2022Purpose of review Hematological malignancies are a kind of systemic cancers mostly related to abnormal differentiation of blood stem cells. Because of the poor prognosis, chemotherapy resistance and common recurrence, new mechanisms and treatment therapies are looking forward to be discovered ...
Wan-Jie, Wang, Ting-Ting, Xu, Jing, Bao
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The role of N6-methyladenosine mRNA in the tumor microenvironment
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021In recent years, the most widely distributed eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A), has received a large amount of interest, in part due to the development and advances of high-throughput RNA sequencing. The effects of m6A mRNA on tumor progression have been the most widely studied, and large amounts of conflicting data
Min, Li, Xuan, Zha, Shengjun, Wang
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RNA N6‐methyladenosine in nonocular and ocular disease
Journal of Cellular Physiology, 2021AbstractN6‐methyladenosine (m6A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in eukaryotic messenger RNA (mRNAs). m6A modification exists in both coding mRNA and noncoding RNAs, and its functions are controlled by methyltransferase, demethylase, and m6A reading proteins.
Nan Wang +5 more
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Research progress on N6-methyladenosine in the human placenta
Journal of Perinatal Medicine, 2022Abstract Objectives N6-methyladenosine (m6A) is one of the most common epigenetic modifications of eukaryotic RNA. Under the jointly reversible regulation of related enzymes, m6A regulates many aspects of RNA, such as translation, stability and degradation.
Wenbo, Zhou +4 more
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The role of N6-methyladenosine (m6A) in eye diseases
Molecular Biology Reports, 2021N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
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Advances in detecting N6-methyladenosine modification in circRNAs
Methods, 2022Circular RNAs (circRNAs) are a class of noncoding RNAs with covalently single-stranded closed loop structures derived from back-splicing event of linear precursor mRNAs (pre-mRNAs). N6-methyladenosine (m6A), the most abundant epigenetic modification in eukaryotic RNAs, has been shown to play a crucial role in regulating the fate and biological function
Lixia, Ma +5 more
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The Functions of N6-Methyladenosine in Nuclear RNAs
Biochemistry (Moscow)N6-methyladenosine (m6A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m6A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m6A-related studies have been focused on the cytoplasmic functions of this ...
Nadezhda A, Zhigalova +3 more
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The momentous role of N6‐methyladenosine in lung cancer
Journal of Cellular Physiology, 2020AbstractLung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNA in eukaryotes ...
Ruiyao Xu +7 more
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The N6-methyladenosine modification in pathologic angiogenesis
Life SciencesThe vascular system is a vital circulatory network in the human body that plays a critical role in almost all physiological processes. The production of blood vessels in the body is a significant area of interest for researchers seeking to improve their understanding of vascular function and maintain normal vascular operation.
Bin, Li +4 more
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Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng +2 more
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