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The role of N6-methyladenosine mRNA in the tumor microenvironment
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021In recent years, the most widely distributed eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A), has received a large amount of interest, in part due to the development and advances of high-throughput RNA sequencing. The effects of m6A mRNA on tumor progression have been the most widely studied, and large amounts of conflicting data
Min, Li, Xuan, Zha, Shengjun, Wang
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Research progress on N6-methyladenosine in the human placenta
Journal of Perinatal Medicine, 2022Abstract Objectives N6-methyladenosine (m6A) is one of the most common epigenetic modifications of eukaryotic RNA. Under the jointly reversible regulation of related enzymes, m6A regulates many aspects of RNA, such as translation, stability and degradation.
Wenbo, Zhou +4 more
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The Functions of N6-Methyladenosine in Nuclear RNAs
Biochemistry (Moscow)N6-methyladenosine (m6A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m6A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m6A-related studies have been focused on the cytoplasmic functions of this ...
Nadezhda A, Zhigalova +3 more
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Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng +2 more
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The role of N6-methyladenosine (m6A) in eye diseases
Molecular Biology Reports, 2021N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
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The N6-methyladenosine modification in pathologic angiogenesis
Life SciencesThe vascular system is a vital circulatory network in the human body that plays a critical role in almost all physiological processes. The production of blood vessels in the body is a significant area of interest for researchers seeking to improve their understanding of vascular function and maintain normal vascular operation.
Bin, Li +4 more
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Advances in detecting N6-methyladenosine modification in circRNAs
Methods, 2022Circular RNAs (circRNAs) are a class of noncoding RNAs with covalently single-stranded closed loop structures derived from back-splicing event of linear precursor mRNAs (pre-mRNAs). N6-methyladenosine (m6A), the most abundant epigenetic modification in eukaryotic RNAs, has been shown to play a crucial role in regulating the fate and biological function
Lixia, Ma +5 more
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The momentous role of N6‐methyladenosine in lung cancer
Journal of Cellular Physiology, 2020AbstractLung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNA in eukaryotes ...
Ruiyao Xu +7 more
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N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Molecular Neurobiology, 2023Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occurs during growing development and senescence. N6-methyladenosine (m6A), as the most common internal modification of eukaryotic mRNA, fine-tunes gene expression by regulating many aspects of mRNA metabolism, such as splicing ...
Lin Zhang, Jian Xia
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Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
Molecular NeurobiologyN6-methyladenosine (m6A) is one of the most common post-transcriptional RNA modifications, which plays a critical role in various bioprocesses such as immunological processes, stress response, cell self-renewal, and proliferation. The abnormal expression of m6A-related proteins may occur in the central nervous system, affecting neurogenesis, synapse ...
Zhuohang, Xian +5 more
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