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N6-Methyladenosine Modification Controls Circular RNA Immunity [PDF]
Molecular Cell, 2019 Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self versus foreign identity in circRNA immunity is unknown. Here, we show that N6-methyladenosine (m6A) RNA modification on human circRNAs inhibits innate immunity.
Y Grace Chen +2 more
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N6-methyladenosine marks primary microRNAs for processing [PDF]
Nature, 2015 The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 and the type III RNase DROSHA. This initial event requires recognition of the junction between the stem and the flanking single-stranded RNA of the pri-miRNA hairpin by DGCR8 followed
Hani Goodarzi +2 more
exaly +5 more sources
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N6-methyladenosine–encoded epitranscriptomics
Nature Structural & Molecular Biology, 2016N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian
Nian, Liu, Tao, Pan
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N6-Methyladenosine in the Heart
2021Similar to DNA modifications, an epitranscriptome of mRNA modifications emerged over the last few years in the cardiovascular system. Specifically, the discovery of the N6-methyladenosine (m6A) as reversible post-transcriptional modification in mRNAs raised recent interest in those modifications in cardiomyocytes and their role in diseased hearts.
Vivien Kmietczyk +2 more
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N6‐methyladenosine (m6A) modification in gynecological malignancies
Journal of Cellular Physiology, 2022AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Chunmei Zhang, Ning Liu
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The evolution of N6-methyladenosine regulators in plants
Methods, 2022As a reversible modification, N6-methyladenosine (m6A) plays key roles in series of biological processes. Although it has been found that m6A modification is regulated by writers, erasers and readers, their evolutionary processes are still not clearly and systematically described. In the present work, we identified 1592 m6A modification regulators from
Meng, Wu +6 more
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N6-methyladenosine in hematological malignancies: a concise review
Current Opinion in Hematology, 2022Purpose of review Hematological malignancies are a kind of systemic cancers mostly related to abnormal differentiation of blood stem cells. Because of the poor prognosis, chemotherapy resistance and common recurrence, new mechanisms and treatment therapies are looking forward to be discovered ...
Wan-Jie, Wang, Ting-Ting, Xu, Jing, Bao
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N6-methyladenosine-mediated gene regulation and therapeutic implications
Trends in Molecular Medicine, 2023N6-methyladenosine (m6A) RNA methylation is the most abundant form of mRNA modification in eukaryotes and is at the front line of biological and biomedical research. This dynamic and reversible m6A RNA modification determines the fates of modified RNA molecules at the post-transcriptional level, affecting almost all important biological processes ...
Yujiao Liu +5 more
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N6-Methyladenosine Regulates Host Responses to Viral Infection
Trends in Biochemical Sciences, 2021Recent discoveries have revealed that, during viral infection, the presence of the RNA modification N6-methyladenosine (m6A) on viral and cellular RNAs has profound impacts on infection outcome. Although m6A directly regulates many viral RNA processes, its effects on cellular RNAs and pathways during infection have only recently begun to be elucidated.
Michael J. McFadden, Stacy M. Horner
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N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Molecular Neurobiology, 2023Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occurs during growing development and senescence. N6-methyladenosine (m6A), as the most common internal modification of eukaryotic mRNA, fine-tunes gene expression by regulating many aspects of mRNA metabolism, such as splicing ...
Lin Zhang, Jian Xia
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