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Advances in detecting N6-methyladenosine modification in circRNAs
Methods, 2022Circular RNAs (circRNAs) are a class of noncoding RNAs with covalently single-stranded closed loop structures derived from back-splicing event of linear precursor mRNAs (pre-mRNAs). N6-methyladenosine (m6A), the most abundant epigenetic modification in eukaryotic RNAs, has been shown to play a crucial role in regulating the fate and biological function
Lixia, Ma +5 more
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The N6-methyladenosine modification in pathologic angiogenesis
Life SciencesThe vascular system is a vital circulatory network in the human body that plays a critical role in almost all physiological processes. The production of blood vessels in the body is a significant area of interest for researchers seeking to improve their understanding of vascular function and maintain normal vascular operation.
Bin, Li +4 more
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RNA epigenetic modification: N6-methyladenosine.
Yi chuan = Hereditas, 2016N(6)-methyladenosine (m(6)A) is one of the most prevalent internal modifications in eukaryotic messenger RNA. The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransferase-like protein 3), METTL14 (Methyltransferase-like protein 14) and WTAP (Wilms tumor 1-associating protein ...
Xiao, Zhang, Gui-fang, Jia
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Recent insights into N6-methyladenosine during viral infection
Current Opinion in Genetics & DevelopmentThe RNA modification of N6-methyladenosine (m6A) controls many aspects of RNA function that impact biological processes, including viral infection. In this review, we highlight recent work that shapes our current understanding of the diverse mechanisms by which m6A can regulate viral infection by acting on viral or cellular mRNA molecules.
Stacy M, Horner, Jordan V, Reaves
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The Functions of N6-Methyladenosine in Nuclear RNAs
Biochemistry (Moscow)N6-methyladenosine (m6A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m6A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m6A-related studies have been focused on the cytoplasmic functions of this ...
Nadezhda A, Zhigalova +3 more
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N6-methyladenosine Methylation of Viral Genes
Future Virology, 2023Jiting Sun, Yan Zhang, Bing Luo
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A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease
Cell Metabolism, 2021Harini Ramalingam +2 more
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The dynamic epitranscriptome: N6-methyladenosine and gene expression control
Nature Reviews Molecular Cell Biology, 2014Kate D Meyer, Samie R Jaffrey
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N6-methyladenosine-dependent regulation of messenger RNA stability
Nature, 2013Xiao Wang, Zhike Lu, Gary C Hon
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