Results 211 to 220 of about 41,505,208 (327)

Genetic variants of IL-13 signalling and human asthma and atopy.

Human Molecular Genetics, 2000
A. Heinzmann, X. Mao, M. Akaiwa, R. T. Kreomer, P. Gao, K. Ohshima, R. Umeshita, R. Umeshita, Yoshito Abe, S. Braun, T. Yamashita, M. H. Roberts, Rie Sugimoto, K. Arima, Y. Arinobu, Bin Yu, S. Kruse, T. Enomoto, Y. Dake, M. Kawai, S. Shimazu, S. Sasaki, C. Adra, M. Kitaichi, H. Inoue, K. Yamauchi, N. Tomichi, F. Kurimoto, N. Hamasaki, J. Hopkin, K. Izuhara, T. Shirakawa, K. Deichmann   +32 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis

British medical journal, 2004
D. Annane, E. Bellissant, P. Bollaert, J. Briegel, D. Keh, Yizhak Kupfer   +5 more
semanticscholar   +1 more source

Epidemiology of sarcopenia among the elderly in New Mexico.

American Journal of Epidemiology, 1998
R. Baumgartner, K. Koehler, D. Gallagher, L. Romero, S. Heymsfield, R. R. Ross, P. Garry, R. Lindeman   +7 more
semanticscholar   +1 more source

Increasing consumption of ultra-processed foods and likely impact on human health: evidence from Brazil

Public Health Nutrition, 2010
C. Monteiro, R. Levy, R. Claro, I. D. de Castro, G. Cannon   +4 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluating the Innovator Training Program: Strengthening Evidence-Based Practice and Building Implementation Capability in the Australian Aged Care Workforce. [PDF]

Australas J Ageing
Champion S, Bilton R, Gordon S.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

Nature, 2001
J. Richmond, R. Weimer, E. Jorgensen
semanticscholar   +1 more source