Results 251 to 260 of about 7,264,527 (287)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Philosophie antique n° 13

Zetesis - Ζήτησις, 2013
openaire   +2 more sources

Sustained Treatment Success With Ustekinumab in Symptomatic Stricturing Crohn's Disease: A Retrospective Single-Arm Observational Cohort Study. [PDF]

MedComm (2020)
Liu J, Hu W, Li S, Hu S, Jiang D, Chen Y.   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

What is the best surgical approach for Pineal Region Tumors? A systematic literature review and anatomical comparative study. [PDF]

Childs Nerv Syst
Palombi D, Agostini L, Brancaleone RM, Offi M, Agosti E, Serioli S, Buffoli B, Rezzani R, Mattogno P, Hirtler L, Fontanella MM, Massimi L, Olivi A, Doglietto F, Tamburrini G.   +14 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

First-in-human, phase 1 study of CM512, a TSLP/IL-13 bispecific antibody, in healthy volunteers: safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity. [PDF]

Front Immunol
Cheng Y, Liu Q, Li M, Xie Y, Men Y, He M, Wang H, Feng X, Zeng M, Zhang L, Chen B, Li J, Feng P.   +12 more
europepmc   +1 more source

Efficacy of chemoradiotherapy in pediatric H3K27M-mutant diffuse intrinsic pontine glioma: a study based on single-center and SEER data. [PDF]

J Neurooncol
Wang D, Liu X, Wang J, Zhang B, Zhai S, Xu J, Wang L, Zheng Y, Wei W, Zhou Y.   +9 more
europepmc   +1 more source

Enhanced collaboration of physicians and speech-language therapists promotes early oral intake in older adults with aspiration pneumonia: A retrospective cohort study. [PDF]

PLoS One
Tawaraya A, Keyaki A.
europepmc   +1 more source

Multicenter Study Suggests Unsupervised Learning Derived From MRI Identifies Prognostic Subgroups in Prostate Cancer Patients After Prostatectomy. [PDF]

Radiol Res Pract
Hu G, Liu X, Chen Z, Zhou B, Gan H, Chen R, Zhou L, Gu Y, Liu X.   +8 more
europepmc   +1 more source