Results 191 to 200 of about 4,530,725 (231)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Long-Term Effectiveness and Safety of LCIG in Romania. 3-year Results from a Prospective, Observational Study (DUOGLOBE). [PDF]

Neuropsychiatr Dis Treat
Szasz JA, Constantin VA, Jianu DC, Dan TF, Dulamea AO, Sabau M, Vasile MT, Bergmann L, Popescu D, Simu MA.   +9 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated <i>In Vivo</i> Efficacy. [PDF]

ACS Med Chem Lett
Liang J, Lambrecht MJ, Huestis MP, Zhu B, Barton LM, Castanedo GM, Ung PM, Larouche-Gauthier R, Jakalian A, Leclerc JP, Yadav A, Haghshenas P, Aubert-Nicol S, Ismaili H, Zhao L, Leblanc M, de Almeida H, Wang Q, Garner T, Tan S, Prangley MS, Pang J, Murray JM, Yu C, Hsu PL, Rutz S, Ishizuka I, Huang H, Gao C, Chen M, Mutter-Rottmayer L, Kakiuchi-Kiyota S, Leung DH, Kou P, Bao L, Wang X.   +35 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Patient experience after pelvic exenteration: chronic pain and quality of life. [PDF]

Support Care Cancer
Louis O, Young J, Power C, Atkin C, Behrenbruch C.   +4 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

So What ? n° 33

Observatoire du Brexit
openaire   +1 more source

Relationship between histopathological findings and RAI in non-papillary follicular cell-derived thyroid carcinoma. [PDF]

J Endocr Soc
Yamazaki H, Sugino K, Katoh R, Kawaida M, Matsuzu K, Kitagawa W, Saito A, Ito K.   +7 more
europepmc   +1 more source