Results 211 to 220 of about 3,747,620 (278)

A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia. [PDF]

Brain
James RE, Bekier M, Lee PJ, Schroeder FA, Evans LT, Wagner FF, Hickman D, Richardson T, Hatzipetros T, Vieira F, Callizot N, Modi S, Hooker JM, Kranz JE, Brown RH, Barmada SJ, Gilbert TM.   +16 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Second-look endoscopy does not reduce delayed bleeding after endoscopic papillectomy: a multicenter propensity score-matched analysis. [PDF]

Ther Adv Gastroenterol
Fujii Y, Matsumoto K, Ueki T, Himei H, Sakakihara I, Ueta E, Toyokawa T, Harada R, Ogawa T, Tomoda T, Kato H, Mitsuhashi T, Sato R, Matsumi A, Miyamoto K, Uchida D, Horiguchi S, Tsutsumi K, Otsuka M.   +18 more
europepmc   +1 more source

GéoNews n°43

Enseigner la géographie
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Bulletin de la SIEY, n° 43

Self XX-XXI, 2023
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comparison of spread patterns and survival outcomes in uterine carcinosarcoma versus grade 3 endometrioid endometrial cancer. [PDF]

J Cancer Res Clin Oncol
Soyak B, Ozgul N.
europepmc   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 4, 2022

Semina: Ciências Agrárias, 2022
doaj  

Editorial do volume 43, n.1 (2025)

Horizontes
Sônia Aparecida Siquelli, Fabiana Rodrigues de Sousa , Márcia Aparecida Amador Mascia , Renata Helena Pin Pucci , Karina Carrasqueira Lopes   +4 more
doaj   +1 more source