Results 201 to 210 of about 18,243,204 (281)

GéoNews n°43

Enseigner la géographie
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Protecting Against Cytoplasmic Protein Aggregates With Cytoplasmic PML Variants. [PDF]

Bio Protoc
Zhu JX, Xia Y, Liu J, Cao L, Hou SX, Wang Y.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Astrocyte-Predominant Tau Pathology in a Patient With VCP R191Q Variant. [PDF]

Neuropathology
Taniguchi D, Tsuyama K, Hatano T, Ashizawa K, Yao T, Fujimaki M, Kanai K, Li Y, Funayama M, Hattori N.   +9 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Functional Activity of TDP-43: A Direct Biomarker for ALS. [PDF]

Biosensors (Basel)
Sonkar KS, Levi D'Ancona V, Cramp J, Shilling H, Giles E, Howell-Bray T, Fillingham B, Cudkowicz ME, Nath A, Rothstein JD, Bowser R, Borroni B, Berry JD, Sadri-Vakili G, Buratti E, Thrippleton IP.   +15 more
europepmc   +1 more source

Bulletin de la SIEY, n° 43

Self XX-XXI, 2023
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Parasymphyseal fracture location in lateral compression pelvic ring injuries: an assessment of reoperation and radiographic displacement in an international multicenter study. [PDF]

Eur J Orthop Surg Traumatol
Hoskins W, Gusho C, Parola R, Bravin D, Crist B, Wenzel A, Bellamy J, Schweser K, Rocca GD, Milby J, Stannard J, Haase D.   +11 more
europepmc   +1 more source