Results 11 to 20 of about 3,450 (152)

GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Polygenic risk score (PRS) assesses genetic risk for diseases, yet some high‐risk individuals avoid illness while low‐risk individuals develop it. We hypothesize that unknown counterfactors may reverse PRS predictions, offering insights into disease mechanisms and interventions.
Li X, Fernandes BS, Liu A, Chen J, Chen X, Zhao Z, Dai Y.   +6 more
europepmc   +2 more sources

Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia. [PDF]

Eur J Neurosci
The mechanisms of novelty detection in the mismatch negativity (MMN) protocol and its disturbances in schizophrenia (SCZ) remain unclear. Here, we developed an integrate‐and‐fire (IAF) spiking neuronal network model to detect multiple types of auditory novelty.
Eissa A, Fredrik Kismul J, Pentz AB, Elvsåshagen T, Metzner C, Akkouh I, Djurovic S, Shadrin A, Linne ML, Einevoll GT, Andreassen OA, Mäki-Marttunen T.   +11 more
europepmc   +2 more sources

Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis. [PDF]

Brain Behav
This study employs Mendelian randomization to demonstrate that neuroticism subclusters (worry, SESA, and depressed affect) influence the risk of developing posttraumatic stress disorder (PTSD). The analysis identifies anorexia nervosa (AN) and panic disorder (PD) as mediating factors, illustrating the complex pathways through which neuroticism ...
You Z, Chen S, Tang J.
europepmc   +2 more sources

Non-viral approaches to gene therapy [PDF]

, 1993
Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Behr, Behr, Blumenthal, Böttger, Cotten, Cotten, Cotten, Cristiano, Curiel, Demeneix, Ellens, Felgner, Felgner, Fitzgerald, Haensler, Haensler, Hawley-Nelson, Huckett, Hyde, Kaneda, Legendre, Leonetri, Midoux, Nabel, Parente, Plank, Plautz, Rosenkranz, Seth, Shen, Stribling, Subbarao, Tang, Tomita, Trubetskoy, Trubetskoy, Ulmer, Wagner, Wagner, Wagner, Wagner, Wagner, Williams, Wu, Zhu   +44 more
core   +1 more source

Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents [PDF]

, 2008
Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block ...
, X. K., A. Guo, A. M. Morawski, A. M. Smith, C. C. Lee, C. Slugovc, C. W. Bielawski, C. W. Bielawski, D. F. Baban, D. W. Bartlett, E. D. Pressly, E. M. Jagoda, E. M. Rohren, F. Henselwood, F. M. Menger, G. J. Liu, H. A. Nabi, H. D. Maynard, H. Kobayashi, H. Maeda, H. Maeda, H. R. Ihre, I. Brigger, J. A. Love, J. B. Matson, J. Heidel, J. R. Heath, K. D. Camm, K. Fukukawa, L. Cai, L. H. Reddy, M. F. Ilker, M. Ferrari, M. L. Adams, M. L. Schipper, M. Licciardi, M. Rawat, N. K. Jain, N. Malik, R. Gref, R. Sinha, S. K. Hobbs, S. M. Lee, S. M. Moghimi, T. L. Choi, V. Bagalkot, V. P. Tochilin, V. P. Torchilin, V. P. Torchilin, V. P. Torchilin, W. J. M. Mulder, W. S. Seo, X. Michalet, Y. Matsumura, Z. Yang   +54 more
core   +3 more sources

Political Struggle in Russia in the Summer of 1645 and Oath of Allegiance Registries [PDF]

, 2013
Статья посвящена политической борьбе в высших кругах России летом 1645 г., связанной со смертью царя Михаила и коронацией его сына Алексея Михайловича.
Liapin, Denis, Ляпин, Д.
core   +1 more source

Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum [PDF]

, 2007
Proline-specific dipeptidyl peptidase-like (DPP IV; EC 3.4.14.5) activity in bovine serum has attracted little attention despite its ready availability and the paucity of useful proline-cleaving enzymes.
Abbott, Barry, Brendan F. O’Connor, Buckley, Bušek, Chruscinska, Ciarán Ó’Fágáin, De Meester, Deborah M. Ruth, Demuth, Dixon, Duke-Cohan, Dunn, Durinx, Edens, Engel, Fersht, FitzGerald, Gonzalez, Gorren, Grasso, Jagath, Khmelnitsky, Kikkawa, Lambeir, Lee, Maes, Mentlein, Mittal, Ogino, Ohkubo, Ohnishi, O’Cuinn, Poltorak, Poltorak, Rasmussen, Sears, Sentandreu, Sheehan, Smith, Séamus J. Buckley, Trubetskoy, Yaron, Yoshimoto   +43 more
core   +1 more source

Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-To [PDF]

, 2011
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic tructures.
Burts, Alan O., Finn, M. G., Grubbs, Robert H., Johnson, Jeremiah A., Koberstein, Jeffrey T., Lim, Yeon-Hee, Lu, Ying Y., Tirrell, David A., Turro, Nicholas J.   +8 more
core   +2 more sources

Accuracy of ultrasound-guided intra-articular injections in guinea pig knees. [PDF]

, 2015
ObjectiveDunkin Hartley guinea pigs, a commonly used animal model of osteoarthritis, were used to determine if high frequency ultrasound can ensure intra-articular injections are accurately positioned in the knee joint.MethodsA high-resolution small ...
Breur, GJ, Goergen, CJ, Panitch, A, Vázquez-Portalatín, N   +3 more
core   +1 more source

The role of the Republic of Kazakhstan in geopolitical transformation in the framework of the «Eurasian project»

Проблемы постсоветского пространства, 2018
In the process of researching the geopolitical transformation of the post-Soviet space as a «Eurasian project», the author uses the method of comparative analysis of the official foreign policy documents of the founding States of the Eurasian economic ...
M. M. Nurtazin
doaj   +1 more source