Results 41 to 50 of about 3,450 (152)

The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General UK Population

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 135-146, October 2025.
ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart   +12 more
wiley   +1 more source

The 'Foce' monumental cemetery in Sanremo: mirror of the city as outstanding tourist destination during the Belle Epoque (1880-1915) [PDF]

open access: yes, 2015
The monumental cemetery of Sanremo, was founded in 1838 and now counts about 2000 graves, one third of which belongs to foreigners, evidences of the city as outstanding tourist destination.
Salvini, Silvia
core   +3 more sources

DNA-condensation, redissolution and mesocrystals induced by tetravalent counterions

open access: yes, 2004
The distance-resolved effective interaction potential between two parallel DNA molecules is calculated by computer simulations with explicit tetravalent counterions and monovalent salt.
  +12 more
core   +1 more source

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]

open access: yes, 2010
Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P.   +9 more
core   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 19, Page 4710-4728, October 2025.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada   +2 more
wiley   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 6, Page 19-31, September 2025.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey   +6 more
wiley   +1 more source

Palamas and Florensky: The Metaphysics of the Heart in Patristic and Russian Philosophical Tradition [PDF]

open access: yes, 2013
Тhis paper focuses on the philosophical issue known as the metaphysics of the heart within Orthodox Christianity – both Russian and Byzantie versions. Russian religious thought is based on patristic tradition.
Kroczak, Justyna
core   +1 more source

Correcting for Genomic Inflation Leads to Loss of Power in Large‐Scale Genome‐Wide Association Study Meta‐Analysis

open access: yesGenetic Epidemiology, Volume 49, Issue 6, September 2025.
ABSTRACT Inflation in genome‐wide association studies (GWAS) summary statistics represents a major challenge, for which correction methods have been developed. These include the genomic control (GC) method, which uses the λ‐value to correct summary statistics, and the linkage disequilibrium score regression (LDSR) method, which uses the LDSR intercept.
Archit Singh   +11 more
wiley   +1 more source

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 5, July 2025.
ABSTRACT A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision‐making, allow for better‐tailored interventions, and avoid treatment failure.
Julia Bäckman   +39 more
wiley   +1 more source

Cross‐Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change

open access: yesHuman Brain Mapping, Volume 46, Issue 6, April 15, 2025.
Multimodal imaging data of 39,325 UK Biobank participants with 2,520 follow‐ups provide insufficient evidence to conclude that brain age reflects the rate of anatomical brain aging. However, modality‐specific differences in brain ages reflect the cross‐sectional state of the brain, highlighting diffusion and multimodal MRI brain age as potentially ...
Max Korbmacher   +9 more
wiley   +1 more source

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