Results 41 to 50 of about 326,728 (258)

Role and specificity of regulatory T cells during retroviral infection [PDF]

, 2009
During chronic viral infection of the hematopoietic system, both virus-mediated and immune-mediated effects may cause bone marrow dysfunction leading to cytopenias. To study the pathological consequences of the T helper response to unresolving chronic
Antunes, I.L., Antunes, I L
core  

A binding process between naïve CD8⁺ T cells and dendritic cells in the ABM simulations.

, 2021
During the binding process, each APC (i.e. dendritic cell that has engulfed antigens) checked the surrounding eight patches. If naïve CD8+T cells appear on these eight patches, an APC checks the number of dendritic cells binding to each naïve CD8+T cell.
Zhenzhen Shi (1437451), Yang Li (7082), Majid Jaberi-Douraki (547680)   +2 more
core   +1 more source

Differential Cytokine Utilization and Tissue Tropism Results in Distinct Repopulation Kinetics of Naïve vs. Memory T Cells in Mice

Frontiers in Immunology, 2019
Naïve and memory T cells co-exist in the peripheral T cell pool, but the cellular mechanisms that maintain the balance and homeostasis of these two populations remain mostly unclear.
Hye Kyung Kim, Hyunsoo Chung, Juntae Kwon, Ehydel Castro, Christopher Johns, Nga V. Hawk, SuJin Hwang, Jung-Hyun Park, Ronald E. Gress   +8 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

, 2001
The enzyme-linked immunospot technique (ELISPOT) relies on the visualization of cytokine secretion by individual T cells following in vitro stimulation with antigen. This assay has been developed and standardized for the quantitative detection of antigen-
Luzia H Carvalho, Carvalho, LH, Fidel Zavala, Julius C.R Hafalla, Hafalla, JC, Zavala, F   +5 more
core   +1 more source

Phenotypic and functional heterogeneity of naïve CD8+ T cells in human peripheral blood during aging

Frontiers in Aging
Naïve CD8+ T cells are key players of adaptive immunity, but their heterogeneity and age-related changes are not fully understood. This study aimed to compare naïve CD8+ T cell subsets defined by different combinations of markers, namely, NCCR7 (CD45RA ...
Luca Pangrazzi, Patrizia Pehl, Lotti Hoffmann, Martin Bachmann, Gabriele Chelini, Michael Keller, Brigitte Jenewein, Maria Cavinato, Birgit Weinberger   +8 more
doaj   +1 more source

The difference of T cell phenotypes in end stage renal disease patients under different dialysis modality

BMC Nephrology, 2019
Background Impaired T cell immune function exists in end-stage renal disease (ESRD) patients. Dialysis treatment may lead to changes in T cell subsets.
Jiao Xiaoyan, Chen Rongyi, Cao Xuesen, Zou Jianzhou, Ji Jun, Ding Xiaoqiang, Yu Xiaofang   +6 more
doaj   +1 more source

Chronic viral infections impinge on naive bystander CD8 T cells

Immunity, Inflammation and Disease, 2020
Introduction Epidemiological data suggest that persistent viral infections impair immune homeostasis and immune responsiveness. Previous studies showed that chronic virus infections negatively impact bystander T‐cell differentiation and memory formation ...
Isabel Barnstorf, Suzanne P. M. Welten, Mariana Borsa, Nicolas S. Baumann, Katharina Pallmer, Nicole Joller, Roman Spörri, Annette Oxenius   +7 more
doaj   +1 more source

Mesenchymal stem cells modulate IL-17 and IL-9 production induced by Th17-inducing cytokine conditions in autoimmune arthritis: an explorative analysis

Advances in Rheumatology, 2023
Background The importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described.
Maximilian Riekert, Giovanni Almanzar, Marc Schmalzing, Norbert Schütze, Franz Jakob, Martina Prelog   +5 more
doaj   +1 more source