Results 21 to 30 of about 326,728 (258)

Persistence of an intact HIV reservoir in phenotypically naive T cells. [PDF]

JCI Insight, 2020
Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear.
Venanzi Rullo E, Pinzone MR, Cannon L, Weissman S, Ceccarelli M, Zurakowski R, Nunnari G, O'Doherty U.   +7 more
europepmc   +2 more sources

In vitro Regulatory T cells Differentiation From Naïve T Cells

Bio-Protocol, 2014
In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key regulators of T-cell tolerance and homeostasis (Sakaguchi, 2004).
Tomas Dalotto , Gabriel Rabinovich, Marian Salatino   +2 more
doaj   +1 more source

Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting [PDF]

International Journal of Nutrition Sciences
Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion.
Sara Assadiasl, Narjes Soleimanifar, Mohammad Hassan Alamolhoda, Hanieh Mojtahedi, Maryam Sadr, Sepehr Safdel, Zahra Mozooni, Mohammad Hossein Nicknam   +7 more
doaj   +1 more source

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source

Metabolic features of naïve and memory CD4⁺T cells in quiescence and during proliferation

Acta Biomedica Scientifica, 2022
Background. Memory CD4+ T cells proliferation is the basis for accelerated secondary immune response. The characteristics of memory CD4+ T cells providing their faster division compared to naive CD4+ T lymphocytes are poorly understood.
V. V. Vlasova, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation

Immunity & Ageing, 2020
Background End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial.
Michiel G. H. Betjes, Anton W. Langerak, Mariska Klepper, Nicolle H. R. Litjens   +3 more
doaj   +1 more source

Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.

PLoS ONE, 2020
Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific ...
Jennifer D Helble, Alexander O Mann, Michael N Starnbach   +2 more
doaj   +1 more source

Establishment and maintenance of the human naïve CD4+ T-cell compartment

Frontiers in Pediatrics, 2016
The naïve CD4+ T-cell compartment is considered essential to guarantee immune competence throughout life. Its replenishment with naïve cells with broad diverse receptor repertoire, albeit with reduced self-reactivity, is ensured by the thymus ...
Susana L Silva, Susana L Silva, Susana L Silva, Ana E Sousa, Ana E Sousa   +4 more
doaj   +1 more source

The influence of three-dimensional structure on naïve T cell homeostasis and aging

Frontiers in Aging, 2022
A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains resting
Simon Lambert, Wenqiang Cao, Wenqiang Cao, Wenqiang Cao, Huimin Zhang, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Cornelia M. Weyand, Jorg J. Goronzy, Jorg J. Goronzy, Claire E. Gustafson, Claire E. Gustafson   +13 more
doaj   +1 more source

In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration. [PDF]

PLoS ONE, 2012
Regulatory T cells (T(reg) cells) are increased in context of malignancies and their expansion can be correlated with higher disease burden and decreased survival.
Marc Beyer, Beatrix Schumak, Martin R Weihrauch, Bettina Andres, Thomas Giese, Elmar Endl, Percy A Knolle, Sabine Classen, Andreas Limmer, Joachim L Schultze   +9 more
doaj   +1 more source