Results 1 to 10 of about 326,728 (258)

STAT3 determines IL-4 signalling outcomes in naïve T cells. [PDF]

Sci Rep, 2021
IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of T cell-based vaccines.
Deimel LP, Li Z, Roy S, Ranasinghe C.
europepmc   +3 more sources

Life and Death of Activated T Cells: How Are They Different from Naïve T Cells? [PDF]

Frontiers in Immunology, 2017
T cells are pivotal in immunity and immunopathology. After activation, T cells undergo a clonal expansion and differentiation followed by a contraction phase, once the pathogen has been cleared.
Andrew M. Lew, Yifan Zhan, Emma M. Carrington, Yuxia Zhang, Susanne Heinzel   +4 more
core   +4 more sources

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source

Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation.
Finney, Olivia C, Riley, Eleanor M, Finney, OC, Lawrence, Emma, Gray, Alice P, Njie, Madi, Walther, M, Walther, Michael, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +11 more
core   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +1 more source

SATB1 ensures appropriate transcriptional programs within naïve CD8(+) T cells

, 2022
Special AT‐binding protein 1 (SATB1) is a chromatin‐binding protein that has been shown to be a key regulator of T‐cell development and CD4(+) T‐cell fate decisions and function.
Day, E Bridie, Nüssing, Simone, Sontani, Yovina, Russ, Brendan E, Goodnow, Christopher C, Daley, Stephen R, Koutsakos, Marios, Lee, Kah, Olshansky, Moshe, Miosge, Lisa A, Roots, Carla M, Barugahare, Adele, Kedzierska, Katherine, Turner, Stephen J   +13 more
core   +2 more sources

IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. [PDF]

, 2005
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites.
Morrot, Alexandre, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Cockburn, Ian A, Carvalho, Luzia H, Zavala, Fidel, Julius C.R. Hafalla, Luzia H. Carvalho, Ian A. Cockburn   +9 more
core   +1 more source

Naïve CD8 T cells are phenotypically heterogenous.

, 2023
(A) tSNE analysis of PBL from Specific pathogen free (SPfree) and Specific pathogen experienced (SPexp) mice 5 days post last infection. Sequential infection of SPfree C57BL/6 mice with PR8-IAV, MCMV-Smith, VacV, att.
Tiffany K. Ybarra (17138446), Thomas S. Griffith (8876915), Vladimir P. Badovinac (17138449), Isaac J. Jensen (4437454), John T. Harty (16852938), Gail A. Bishop (10076752), Patrick W. McGonagil (17138443), Roger R. Berton (17138440)   +7 more
core   +1 more source

Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. [PDF]

, 2003
Following immunization with Plasmodium yoelii sporozoites, the CD8(+) T cell population specific for the SYVPSAEQI epitope expressed in sporozoite and liver stages of this malaria parasite revealed the existence of a short term Ag presentation process ...
Morrot, Alexandre, Hafalla, Julius CR, Milon, Geneviève, Lafaille, Juan J, Zavala, Fidel, Sano, Gen-Ichiro   +5 more
core   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source