Results 31 to 40 of about 326,728 (258)

CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults. [PDF]

Immun Ageing
Background The T cell compartment undergoes significant age-related changes, contributing to the decline of the adaptive immune system and increasing the risk of suboptimal antibody responses to vaccines in older adults.
Cevirgel A, Vos M, Bijvank E, van Beek J, van der Heiden M, Buisman AM, van Baarle D.   +6 more
europepmc   +2 more sources

Naïve T cell homeostasis regulated by stress responses and TCR signaling

Frontiers in Immunology, 2015
The survival of naïve T cells is believed to require signals from TCR-pMHC interactions and cytokines such as IL-7. In contrast, signals that negatively impact naïve T cell survival are less understood.
Daisuke eKamimura, Daisuke eKamimura, Toru eAtsumi, Toru eAtsumi, Andrea eStofkova, Naoki eNishikawa, Takuto eOhki, Hironao eSuzuki, Hironao eSuzuki, Kokichi eKatsunuma, Jing-jing eJiang, Jing-jing eJiang, Hidenori eBando, Hidenori eBando, Jie eMeng, Jie eMeng, Lavannya eSabharwal, Lavannya eSabharwal, Hideki eOgura, Hideki eOgura, Toshio eHirano, Yasunobu eArima, Yasunobu eArima, Masaaki eMurakami, Masaaki eMurakami   +24 more
doaj   +1 more source

PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells

FEBS Open Bio, 2020
C‐C chemokine receptor type 7 (CCR7) is expressed on naïve T cells, B cells, and activated dendritic cells (DCs). We previously demonstrated that the transcription factor PU.1/Spi1 positively regulates the expression of CCR7 in DCs. In the present study,
Takuya Yashiro, Hiromi Takeuchi, Kazumi Kasakura, Chiharu Nishiyama   +3 more
doaj   +1 more source

Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia

Frontiers in Immunology, 2021
The interplay between T- and B-cell compartments during naïve, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B ...
Pavel V. Shelyakin, Ksenia R. Lupyr, Ksenia R. Lupyr, Evgeny S. Egorov, Ilya A. Kofiadi, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Sofya A. Kasatskaya, Sofya A. Kasatskaya, Sofya A. Kasatskaya, Valeriia V. Kriukova, Valeriia V. Kriukova, Irina A. Shagina, Irina A. Shagina, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, Tatiana O. Nakonechnaya, Elena A. Latysheva, Irina A. Manto, Musa R. Khaitov, Sergey A. Lukyanov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Olga V. Britanova   +24 more
doaj   +1 more source

Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection

Immunity & Ageing, 2018
Background A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells.
Kathleen G. Lanzer, Tres Cookenham, William W. Reiley, Marcia A. Blackman   +3 more
doaj   +1 more source

ANTI-APOPTOTIC EFFECT OF CD95 RECEPTOR IN NA VE CD8+ T-LYMPHOCYTES IN CHILDREN WITH ACUTE INFECTIOUS MONONUCLEOSIS

Инфекция и иммунитет, 2016
Acute infectious mononucleosis is a widespread viral disease, which most often manifests in childhood. The development of acute infectious mononucleosis is accompanied by the change of the CD4+/CD8+ T-lymphocytes ratio and the increase of the virus ...
E. N. Filatova, E. V. Anisenkova, N. B. Presnyakova, T. D. Sycheva, E. A. Kulova, O. V. Utkin   +5 more
doaj   +1 more source

Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infection.

, 2007
Immunity to Plasmodium liver stages in individuals in malaria-endemic areas is inextricably linked to concomitant blood-stage parasitemia. Although Plasmodium sporozoite infection induces measurable CD8+ T cell responses, the development of memory T ...
Dabeiba Bernal‐Rubio, Rai, Urvashi, Julius C. R. Hafalla, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Bernal-Rubio, Dabeiba   +9 more
core   +1 more source

Thymic Involution and Altered Naive CD4 T Cell Homeostasis in Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Circulating T helper cells with a type 17-polarized phenotype (TH17) and expansion of aquaporin-4 (AQP4)-specific T cells are frequently observed in patients with neuromyelitis optica spectrum disorder (NMOSD).
Haoxiao Chang, Haoxiao Chang, Hengri Cong, Huabing Wang, Li Du, De-Cai Tian, Yuetao Ma, Yun Xu, Yupeng Wang, Linlin Yin, Linlin Yin, Linlin Yin, Xinghu Zhang   +12 more
doaj   +1 more source

Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25− T Cell Subsets in Transplant Tolerance

Frontiers in Immunology, 2017
Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired.
Bruce M. Hall, Catherine M. Robinson, Karren M. Plain, Karren M. Plain, Nirupama D. Verma, Giang T. Tran, Masaru Nomura, Masaru Nomura, Nicole Carter, Nicole Carter, Rochelle Boyd, Rochelle Boyd, Suzanne J. Hodgkinson   +12 more
doaj   +1 more source

TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice. [PDF]

PLoS ONE, 2012
The PI3K-Akt-mTOR pathway plays crucial roles in regulating both innate and adaptive immunity. However, the role of TSC1, a critical negative regulator of mTOR, in peripheral T cell homeostasis remains elusive.
Lianjun Zhang, Hongbing Zhang, Lanlan Li, Yi Xiao, Enyu Rao, Zhuang Miao, Hui Chen, Lina Sun, Hongran Li, Guangwei Liu, Yong Zhao   +10 more
doaj   +1 more source