Results 31 to 40 of about 676,875 (252)
Papeles del CEIC: International Journal on Collective Identity Research, 2007 El fútbol fue un lugar privilegiado en donde se construían narrativas nacionales. Hoy ya no es un eficaz fundador de narrativas identitarias. El más popular de los deportes en la Argentina ya no es una zona de anclaje de lo nacional sino, por el ...
José Garriga Zucal
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O PODER NACIONAL E A SEGURANÇA NACIONAL
Revista da Escola Superior de Guerra, 2023 .
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Inteligencia nacional y estrategia de ciberseguridad nacional [PDF]
, 2020 Hoy, el ambiente cibernético es definido como un nuevo ecosistema, que sirve como herramienta para actores de diversos tipos, sean estos estatales o no estatales (militares, civiles y paraestatales). Así, el ciberespacio cobra distintas dimensiones referidas a la seguridad, la inteligencia y cuestiones de defensa nacional.
Albarracín Keticoglu, Ana Alicia
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Revista de Direito Sanitário, 2001 Resenha sobre a publicação "Políticas públicas: a responsabilidade do administrador e o Ministério Público" de Luiza Cristina Fonseca Frischeisen (Editora Max Limonad, São Paulo, 2000).
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source