Results 121 to 130 of about 133,635 (341)

The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection

Polish Journal of Thoracic and Cardiovascular Surgery
The increasing trend of cardiac diseases is becoming a major threat globally. Cardiac activities are based on integrated action potential through electronic flux changes within intra- and extracellular molecular activities.
Fazle Kibria, Sudip Kumar Das, Md Sahidul Arefin   +2 more
doaj   +1 more source

Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways [PDF]

, 2017
Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD,
Alejandro Pacheco, Alejandro Vallejos, Cesar Echeverria, Erico Segovia, Felipe Simon, Felipe Simon, Maria E. Sanhueza, Miriam Alvo, Pablo Tapia, Ricardo Armisen, Ricardo Armisen, Rubén Torres, Rubén Torres, Sebastian Gatica   +13 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

NMN-Adenylyltransferase und NAD+-Kinase

, 2003
Die beiden Nukleotide NAD+ und NADP+ sind essentielle Coenzyme für zahlreiche Redoxreaktionen in allen bekannten Organismen. Sie sind außerdem Vorstufen für Signalmoleküle und Substrate für kovalente Proteinmodifikationen in höheren Eukaryoten. Bislang lagen zu den essentiellen Enzymen der NAD(P)+-Synthese, der NMNAT und der NAD+-Kinase, keine ...
openaire   +2 more sources

Cofactor Fingerprinting with STD NMR to Characterize Proteins of Unknown Function: Identification of a Rare cCMP Cofactor Preference [PDF]

, 2004
Proteomics efforts have created a need for better strategies to functionally categorize newly discovered proteins. To this end, we have employed saturation transfer difference NMR with pools of closely related cofactors, to determine cofactor preferences.
Sem, Daniel, Yao, Huili
core   +1 more source

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]

, 2014
Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph, Svensson, Kristoffer   +1 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Fluorometric procedures for measuring triglyceride concentrations in small amounts of tissue and plasma.

Journal of Lipid Research, 1988
It has been previously shown that triglycerides can be specifically hydrolyzed by lipase from Rhizopus arrhizus in the presence of hog liver esterase and sodium dodecyl sulfate.
P M Nemeth, O E Hitchins, L Solanki, T G Cole   +3 more
doaj  

Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries

Arquivos Brasileiros de Cardiologia
Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted.
Janaina A. Simplicio, Ulisses Vilela Hipólito, Gabriel Tavares do Vale, Glaucia Elena Callera, Camila André Pereira, Rhian M Touyz, Rita de Cássia Tostes, Carlos R. Tirapelli   +7 more
doaj   +1 more source

Pigeon‐Liver NAD Kinase [PDF]

European Journal of Biochemistry, 1975
NAD kinase was purified from pigeon liver by an improved procedure which included chromatography on phosphocellulose. The resultant preparation was homogeneous as judged by gel electrophoresis, but electrofocusing gave indications of heterogeneity. The enzyme appeared to be of molecular weight 270000, and to consist of subunits of molecular weight ...
openaire   +2 more sources