MNADK, a novel liver-enriched mitochondrion-localized NAD kinase
Biology Open, 2013 Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
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Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase. [PDF]
FEBS J, 2023 Rahimova R +8 more
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Probing binding requirements of NAD kinase with modified substrate (NAD) analogues
Bioorganic & Medicinal Chemistry Letters, 2007 Synthesis of novel NAD(+) analogues that cannot be phosphorylated by NAD kinase is reported. In these analogues the C2' hydroxyl group of the adenosine moiety was replaced by fluorine in the ribo or arabino configuration (1 and 2, respectively) or was inverted into arabino configuration to give compound 3.
Laurent Bonnac +11 more
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Evidence for two NAD kinases in Salmonella typhimurium [PDF]
Journal of Bacteriology, 1994 The electron-carrying cofactor NADP is formed by phosphorylation of NAD. A strategy for the isolation of NAD kinase mutants revealed two classes of temperature-sensitive mutations, nadF and nadG, mapping at min 13 and 72 of the Salmonella chromosome.
W. C. Cheng, J R Roth
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Nicotinamide riboside kinase structures reveal new pathways to NAD+.
PLoS Biology, 2007 The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and ...
Wolfram Tempel +10 more
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Oxidative Stress Induces the Phosphorylation of NAD<sup>+</sup> to NADP<sup>+</sup> by NAD Kinase in Cultured Primary Rat Astrocytes. [PDF]
Neurochem ResWillker JE, Watermann P, Dringen R.
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Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice [PDF]
Redox BiologyImbalance of Nicotinamide adenine dinucleotide (NAD+) homeostasis is a key contributor to various cardiac pathologies, including doxorubicin (DOX)-induced cardiomyopathy (DIC). The kynurenine pathway (KP), initiated by indoleamine 2,3-dioxygenase 1 (IDO1)
Danlei Li +7 more
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Frontiers in Immunology, 2022 Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and
Claudia C. S. Chini +17 more
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Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD⁺ levels in liver tissue [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Multiple sclerosis (MS) is a chronic inflammatory disease affecting sensory and motor function in the central nervous system. Physical activities in the prevention and treatment of such conditions have shown promising results.
Maryam Nazari +3 more
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Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants
Plant Signaling & Behavior, 2023 Arabidopsis NADK2 (NAD kinase 2) is a chloroplast-localized enzyme involved in NADP+ synthesis, which acts as the final electron acceptor in the photosynthetic electron transfer chain.
chaomurilege +5 more
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