(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase [PDF]
ACS Medicinal Chemistry Letters, 2022 Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. To discover NADK-targeted probes, a high-throughput screening assay was established and optimized with a Z ...
Tonghai Liu +13 more
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NAD Kinases Use Substrate-assisted Catalysis for Specific Recognition of NAD [PDF]
Journal of Biological Chemistry, 2007 Here we describe the crystal structures of the NAD kinase (LmNADK1) from Listeria monocytogenes in complex with its substrate NAD, its product NADP, or two synthesized NAD mimics. We identified one of the NAD mimics, di-adenosine diphosphate, as a new substrate for LmNADK1, whereas we showed that the closely related compound di-5'-thioadenosine is a ...
G. Poncet-Montange +4 more
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NAD Kinase in Higher Plants [PDF]
Plant Physiology, 1966 NAD kinase was exclusively found in the soluble portion of the cell components. The enzyme was purified about 100-fold from sucrose extracts of spinach leaves.Plant NAD kinase catalyzes formation of NADP from NAD, ATP, and Mg(++), but scarcely any formation of NADPH from NADH. NADH was a very potent competitive inhibitor of NAD phosphorylation by plant
Yukio Yamamoto
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The Substrate Specificity of Pigeon Liver NAD Kinase [PDF]
European Journal of Biochemistry, 1969 The specificity of pigeon liver NAD kinase for both substrates and for divalent cations has been investigated. 2. The enzyme is activated by Mg++, Co++, Mn++, and Zn++ only: the ATP‐metal complexes have different Km, values but the maximum velocities of the reactions are the same. 3.
D.K. Apps
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LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner [PDF]
J Exp Clin Cancer Res, 2023 Yi Chen +8 more
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Molecular characterization of Escherichia coli NAD kinase [PDF]
European Journal of Biochemistry, 2001 NAD kinase was purified to homogeneity from Escherichia coli MG1655. The enzyme was a hexamer consisting of 30 kDa subunits and utilized ATP or other nucleoside triphosphates as phosphoryl donors for the phosphorylation of NAD, most efficiently at pH 7.5 and 60 °C.
Shigeyuki Kawai +4 more
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The reaction of pigeon liver NAD kinase with bromoacetyl pyridine [PDF]
FEBS Letters, 1969 D.K. Apps
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Downregulation of
Aging CellGuan‐Jie Li +6 more
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Frontiers in Immunology, 2022 Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and
Claudia C. S. Chini +17 more
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NAD+ Kinase as a Therapeutic Target in Cancer [PDF]
Clinical Cancer Research, 2016 Abstract NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP+ is then reduced to NADPH by dehydrogenases, in particular glucose-6-phosphate dehydrogenase and the malic enzymes.
Kathleen W. Scotto +5 more
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