(-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase. [PDF]
ACS Med Chem Lett, 2022 Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. To discover NADK-targeted probes, a high-throughput screening assay was established and optimized with a Z ...
Liu T +13 more
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NAD Kinases Use Substrate-assisted Catalysis for Specific Recognition of NAD [PDF]
Journal of Biological Chemistry, 2007 Here we describe the crystal structures of the NAD kinase (LmNADK1) from Listeria monocytogenes in complex with its substrate NAD, its product NADP, or two synthesized NAD mimics. We identified one of the NAD mimics, di-adenosine diphosphate, as a new substrate for LmNADK1, whereas we showed that the closely related compound di-5'-thioadenosine is a ...
G. Poncet-Montange +4 more
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NAD Kinase in Higher Plants [PDF]
Plant Physiology, 1966 NAD kinase was exclusively found in the soluble portion of the cell components. The enzyme was purified about 100-fold from sucrose extracts of spinach leaves.Plant NAD kinase catalyzes formation of NADP from NAD, ATP, and Mg(++), but scarcely any formation of NADPH from NADH. NADH was a very potent competitive inhibitor of NAD phosphorylation by plant
Yukio Yamamoto
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essential enzymes of NAD(P)+ synthesis [PDF]
, 2003 Titelseite Gutachter Inhaltsverzeichnis 1\. Einleitung 2\. Material und Methoden 3\. Ergebnisse 4\. Diskussion und Ausblick 5\. Zusammenfassung 6\. Abstract 7\. Literatur 8\. Abkürzungen 9\. Abbildungs- und Tabellenverzeichnis 10\.
Berger, Felicitas
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The Substrate Specificity of Pigeon Liver NAD Kinase [PDF]
European Journal of Biochemistry, 1969 The specificity of pigeon liver NAD kinase for both substrates and for divalent cations has been investigated. 2. The enzyme is activated by Mg++, Co++, Mn++, and Zn++ only: the ATP‐metal complexes have different Km, values but the maximum velocities of the reactions are the same. 3.
D.K. Apps
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Identification and characterization of a human mitochondrial NAD kinase [PDF]
Nature Communications, 2012 NAD kinase is the sole NADP(+) biosynthetic enzyme. Despite the great significance of NADP(+), to date no mitochondrial NAD kinase has been identified in human, and the source of human mitochondrial NADP(+) remains elusive. Here we present evidence demonstrating that a human protein of unknown function, C5orf33, is a human mitochondrial NAD kinase ...
Kazuto Ohashi +2 more
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Molecular characterization of Escherichia coli NAD kinase [PDF]
European Journal of Biochemistry, 2001 NAD kinase was purified to homogeneity from Escherichia coli MG1655. The enzyme was a hexamer consisting of 30 kDa subunits and utilized ATP or other nucleoside triphosphates as phosphoryl donors for the phosphorylation of NAD, most efficiently at pH 7.5 and 60 °C.
Shigeyuki Kawai +4 more
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LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner. [PDF]
J Exp Clin Cancer Res, 2023 Chen Y +8 more
europepmc +3 more sources
The reaction of pigeon liver NAD kinase with bromoacetyl pyridine [PDF]
FEBS Letters, 1969 D.K. Apps
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Cryo-EM structure and regulation of human NAD kinase. [PDF]
Sci AdvPraharaj PP +18 more
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