Results 21 to 30 of about 70,171 (129)
The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism [PDF]
Journal of Molecular Endocrinology, 2018 The concept of replenishing or elevating NAD+availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+availability such that strategies to intervene in the clinical setting are able to be fully realised.
Gareth G. Lavery, Rachel Fletcher
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Crystal Structures of an NAD Kinase from Archaeoglobus fulgidus in Complex with ATP, NAD, or NADP [PDF]
Journal of Molecular Biology, 2005 NAD kinase is a ubiquitous enzyme that catalyzes the phosphorylation of NAD to NADP using ATP or inorganic polyphosphate (poly(P)) as phosphate donor, and is regarded as the only enzyme responsible for the synthesis of NADP. We present here the crystal structures of an NAD kinase from the archaeal organism Archaeoglobus fulgidus in complex with its ...
Yun Lou +6 more
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Properties of a Protein Activator of NAD Kinase from Plants [PDF]
Plant Physiology, 1977 Purification of pea (Pisum sativum) seedling NAD kinase by DEAE-cellulose column chromatography resulted in loss of activity, due to dissociation of an activator from the enzyme. The purified enzyme preparation, which was almost completely inactive, regained the activity when the activator was added back.The activator was purified 320-fold by ion ...
Shoshi Muto, Shigetoh Miyachi
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Molecular properties, functions, and potential applications of NAD kinases [PDF]
Acta Biochimica et Biophysica Sinica, 2009 NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of
Feng Shi +3 more
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Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases [PDF]
Oncogene, 2014 Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability and metabolism. Although these NAD(+)-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated signaling targets remain under-studied.
Yeung, Fan +9 more
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Photoactivation of NAD Kinase through Phytochrome [PDF]
Plant Physiology, 1975 The specificities of phosphate donors and the effects of metal chelating agents and divalent metal ions on NAD kinase activation by phytochrome-far red-absorbing form (Pfr) were examined. ATP was the most efficient phosphorylating agent. Uridine 5'-triphosphate, cytidine 5'-triphosphate (CTP), inosine 5'-triphosphate, and guanosine 5'-triphosphate in ...
Yukio Yamamoto, Takafumi Tezuka
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NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase
Nature Metabolism, 2020 Dihydronicotinamide riboside (NRH) has been suggested to act as a precursor for the synthesis of NAD+, but the biochemical pathway converting it has been unknown. Here, we show that NRH can be converted into NAD+ via a salvage pathway in which adenosine kinase (ADK, also known as AK) acts as an NRH kinase.
Yue Yang +3 more
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NMN-Adenylyltransferase und NAD+-Kinase
, 2003 Die beiden Nukleotide NAD+ und NADP+ sind essentielle Coenzyme für zahlreiche Redoxreaktionen in allen bekannten Organismen. Sie sind außerdem Vorstufen für Signalmoleküle und Substrate für kovalente Proteinmodifikationen in höheren Eukaryoten. Bislang lagen zu den essentiellen Enzymen der NAD(P)+-Synthese, der NMNAT und der NAD+-Kinase, keine ...
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European Journal of Biochemistry, 1975 NAD kinase was purified from pigeon liver by an improved procedure which included chromatography on phosphocellulose. The resultant preparation was homogeneous as judged by gel electrophoresis, but electrofocusing gave indications of heterogeneity. The enzyme appeared to be of molecular weight 270000, and to consist of subunits of molecular weight ...
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Molecular cloning and identification ofUTR1of a yeastSaccharomyces cerevisiaeas a gene encoding an NAD kinase [PDF]
, 2001 Shigeyuki Kawai +3 more
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