Results 311 to 320 of about 127,437 (365)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways. [PDF]

World J Cardiol
Maiese K.
europepmc   +1 more source

Matrix Viscoelasticity Orchestrates Osteogenesis via Mechanotransduction Mediated Metabolic Switch in Macrophages

Advanced Healthcare Materials, EarlyView.
Fast‐relaxation viscoelastic hydrogel triggers a metabolic shift in macrophages, favoring oxidative phosphorylation (OXPHOS) over glycolysis via vasodilator‐stimulated phosphoprotein (VASP) / hypoxia‐inducible factor 1 alpha (HIF1α) signaling meditated mechanotransdution, thereby enhancing their capacity to recruit mesenchymal stem cells (MSCs) and ...
Dihao Tao, Hanzhe Wang, Shiping Chang, Jiayu Cheng, Ningning Da, Li Zhang, Jianhua Yang, Wenzhe Wang, Feng Xu, Bei Li   +9 more
wiley   +1 more source

Sirtuins in kidney homeostasis and disease: where are we now? [PDF]

Front Endocrinol (Lausanne)
Fan Z, Wei X, Zhu X, Du Y.
europepmc   +1 more source

A ketogenic diet regulates microglial activation to treat drug addiction. [PDF]

Front Pharmacol
Ji J, Tang Y.
europepmc   +1 more source

Involvement of SIRT1-mediated aging in liver diseases. [PDF]

Front Cell Dev Biol
Zhang Y, Gong C, Tao L, Zhai J, Huang F, Zhang S.   +5 more
europepmc   +1 more source

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

Erdem A, Kaye S, Caligiore F, Johanns M, Leguay F, Schuringa JJ, Ito K, Bommer G, van Gastel N.   +8 more
europepmc   +1 more source

Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis. [PDF]

Exp Mol Med
Han J, Kim YH, Han S.
europepmc   +1 more source

Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models. [PDF]

Sci Rep
Curran CS, Cui X, Li Y, Gamble T, Sun J, Minkove S, Livinski AA, Eichacker PQ, Torabi-Parizi P.   +8 more
europepmc   +1 more source

The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression. [PDF]

Cancer Med
Lu Z, Zhang C, Zhang J, Su W, Wang G, Wang Z.   +5 more
europepmc   +1 more source