Results 31 to 40 of about 127,437 (365)
Cells, 2023 Nicotinamide adenine dinucleotide (NAD) serves as a substrate for protein deacetylases sirtuins and poly(ADP-ribose) polymerases, which are involved in the regulation of DNA double-strand break (DSB) repair molecular machinery by various mechanisms ...
Maria Svetlova +3 more
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Over-expression of NAD kinase in Corynebacterium crenatum and its Impact on L-Arginine Biosynthesis [PDF]
, 2013 Purpose: To improve the biosynthesis of L-arginine by overexpressing homologous NAD kinase (ppnk) in Corynebacterium crenatum SYPA5-5 and to study its impact in presence of high (HOS) and low oxygen supply (LOS).Methods: A recombinant plasmid (pJC1-tac ...
Dou, W +4 more
core +2 more sources
Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants
Frontiers in Plant Science, 2019 Calcium (Ca2+) signaling and nicotinamide adenine dinucleotide (NAD) signaling are two basic signal regulation pathways in organisms, playing crucial roles in signal transduction, energy metabolism, stress tolerance, and various developmental processes ...
Li Tai +9 more
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Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. [PDF]
, 2013 Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei. To discover new drugs against the disease, one may use drugs in the clinic for other indications whose chemical scaffolds can be optimized via a medicinal chemistry ...
Abagyan, Ruben +7 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2018 Cumulating evidence has indicated NAD+ deficiency as a common central pathological factor of multiple diseases and aging. NAD+ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does
Jie Zhang +5 more
doaj +1 more source
Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. [PDF]
PLoS ONE, 2013 Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2.
Su-Jung Yang +7 more
doaj +1 more source
Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]
, 2019 Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J. +2 more
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MNADK, a novel liver-enriched mitochondrion-localized NAD kinase
Biology Open, 2013 Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj +1 more source
Journal of Diabetes Investigation, 2020 One of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic oxidized to reduced forms of the nicotinamide adenine dinucleotide ratio (NAD+/NADH also known as pseudohypoxia) caused by oxidation of excessive substrates ...
Lan Fan, Jose M. Cacicedo, Yasuo Ido
doaj +1 more source
A fluorometric method for the assay of protein kinase activity [PDF]
, 2018 Protein kinases constitute one of the largest protein families in nature. Current methods to assay their activity involve the use of radioactive ATP or very expensive reagents.
Figueroa, Carlos Maria +4 more
core +1 more source