Results 31 to 40 of about 71,648 (238)
Journal of Diabetes Investigation, 2020 One of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic oxidized to reduced forms of the nicotinamide adenine dinucleotide ratio (NAD+/NADH also known as pseudohypoxia) caused by oxidation of excessive substrates ...
Lan Fan, Jose M. Cacicedo, Yasuo Ido
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Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. [PDF]
PLoS ONE, 2013 Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2.
Su-Jung Yang +7 more
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MNADK, a novel liver-enriched mitochondrion-localized NAD kinase
Biology Open, 2013 Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
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Nutraceutical activation of Sirt1: a review
Open Heart, 2022 The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an ‘anti-aging’ enzyme. Practical measures which might
James J DiNicolantonio +2 more
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The effector AvrRxo1 phosphorylates NAD in planta. [PDF]
PLoS Pathogens, 2017 Gram-negative bacterial pathogens of plants and animals employ type III secreted effectors to suppress innate immunity. Most characterized effectors work through modification of host proteins or transcriptional regulators, although a few are known to ...
Teja Shidore +7 more
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Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
Nature Communications, 2019 Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat +12 more
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Frontiers in Immunology, 2019 The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the first
Georg Gruenbacher +7 more
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Frontiers in Endocrinology, 2022 Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann +8 more
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Journal of Ginseng Research, 2020 Background: The replicative senescence of human dermal fibroblasts (HDFs) is accompanied by growth arrest. In our previous study, the treatment of senescent HDFs with Rg3(S) lowered the intrinsic reactive oxygen species (ROS) levels and reversed cellular
Kyeong-Eun Yang +7 more
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Biomolecules, 2022 Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major
Amany Iskander, Liang-Jun Yan
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