Results 41 to 50 of about 133,635 (341)

Artificial Photosynthesis Would Unify the Electricity-Carbohydrate-Hydrogen Cycle for Sustainability [PDF]

, 2010
Sustainable development requires balanced integration of four basic human needs – air (O2/CO2), water, food, and energy. To solve key challenges, such as CO2 fixation, electricity storage, food production, transportation fuel production, water ...
Yi-Heng Percival Zhang
core   +2 more sources

Nutraceutical activation of Sirt1: a review

Open Heart, 2022
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an ‘anti-aging’ enzyme. Practical measures which might
James J DiNicolantonio, Mark F McCarty, James H O'Keefe   +2 more
doaj   +1 more source

Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]

, 2015
Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk, Contestabile, Roberto, DI SALVO, Martino Luigi, Garik, Mkrtchyan, Lucien, Bettendorff, Parroni, Alessia, Thilo, Kaehne, Vasily, Aleshin, Victoria, Bunik, Yulia, Parkhomenko   +9 more
core   +1 more source

Comprehensive structural classification of ligand binding motifs in proteins [PDF]

, 2008
Comprehensive knowledge of protein-ligand interactions should provide a useful basis for annotating protein functions, studying protein evolution, engineering enzymatic activity, and designing drugs.
Akira R. Kinjo, Altschul, Andreeva, Bachhawat, Barber, Berman, Berry, Beuth, Brakoulias, Carvalho, Chen, Davies, Diamond, Dias, Du, Dunn, Friedberg, Garcia-Molina, Gold, Goldstein, Gonzalez, Grishin, Grishin, Gross, Guilloteau, Gutteridge, Haruki Nakamura, Herter, Hoff, Ikura, Jonassen, Jones, Kawabata, Kawabata, Kinjo, Kinoshita, Kinoshita, Kobayashi, Kolodny, Krishna, Krishna, Krissinel, Lang, Laronde-Leblanc, Lawler, Lee, Malikayil, Minai, Murzin, Nagano, Orengo, Pattabhi, Polacco, Porter, Ridder, Rognan, Russell, Schubert, Shulman-Peleg, Standley, Stark, Stewart, Stoll, Tari, Tari, Taylor, Wallace, Wangikar, Watts, Westbrook, Whitlow, Wolfson, Xiao, Xie   +73 more
core   +2 more sources

The Human G Protein-Coupled ATP Receptor P2Y11 Is Associated With IL-10 Driven Macrophage Differentiation

Frontiers in Immunology, 2019
The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the first
Georg Gruenbacher, Hubert Gander, Andrea Rahm, Gabriele Dobler, Astrid Drasche, Jakob Troppmair, Walter Nussbaumer, Martin Thurnher   +7 more
doaj   +1 more source

Evidence for two NAD kinases in Salmonella typhimurium [PDF]

Journal of Bacteriology, 1994
The electron-carrying cofactor NADP is formed by phosphorylation of NAD. A strategy for the isolation of NAD kinase mutants revealed two classes of temperature-sensitive mutations, nadF and nadG, mapping at min 13 and 72 of the Salmonella chromosome.
Weili Cheng, John R. Roth
openaire   +3 more sources

NOD2 and inflammation: current insights [PDF]

, 2018
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore, Negroni, Anna, Pierdomenico, Maria, Stronati, Laura   +3 more
core   +2 more sources

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Nature Communications, 2019
Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Carles Canto   +12 more
doaj   +1 more source

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Frontiers in Endocrinology, 2022
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann, Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, Sandip K. Patel, Joanna Bons, Birgit Schilling, Cristina Aguayo-Mazzucato, Christopher D. Wiley   +8 more
doaj   +1 more source

NADK as a molecular marker to distinguish between alcohol- and non-alcohol-associated liver cirrhosis: A pilot study [PDF]

Clinical & Experimental Hepatology
Ki-Hoon Park, Seok-Hyung Kim, So-Woon Kim, Kiyong Na, Sunyoung Kim, Young-Il Choi, Hyung-Joo Chung, Junyang Jung, Na Young Jeong   +8 more
doaj   +2 more sources