Results 51 to 60 of about 998,124 (249)

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

open access: yesNature Communications, 2019
Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat   +12 more
doaj   +1 more source

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

open access: yesFrontiers in Endocrinology, 2022
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann   +8 more
doaj   +1 more source

Identification of the Arabidopsis Calmodulin-Dependent NAD+ Kinase That Sustains the Elicitor-Induced Oxidative Burst1

open access: yesPlant Physiology, 2019
A long-sought calmodulin- and Ca2+-dependent NAD kinase that is conserved in the plant lineage is the missing link between Ca2+ signaling, metabolism, and the oxidative burst. NADP(H) is an essential cofactor of multiple metabolic processes in all living
Elisa Dell’Aglio   +10 more
semanticscholar   +1 more source

Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]

open access: yesJournal of Chemical Information and Modeling, 2018, 2018
Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv   +1 more source

Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products

open access: yesBiomolecules, 2022
Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major
Amany Iskander, Liang-Jun Yan
doaj   +1 more source

Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network [PDF]

open access: yes, 2010
Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of proteins within the cell.
arxiv   +1 more source

Advance in Reversible Covalent Kinase Inhibitors [PDF]

open access: yesarXiv, 2021
Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv  

Using the structural kinome to systematize kinase drug discovery [PDF]

open access: yesarXiv, 2021
Kinase-targeted drug design is challenging. It requires designing inhibitors that can bind to specific kinases when all kinase catalytic domains share a common folding scaffold that binds ATP. Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
arxiv  

NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2015
Significance Metabolism relies on a set of molecules that provide the chemical framework for all cellular activities. Among these molecules is NADP, a metabolite synthesized from vitamin B3 that is critical for basic metabolism, calcium signaling, and ...
Nick R. Love   +8 more
semanticscholar   +1 more source

A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]

open access: yesarXiv, 2022
The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv  

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