Results 71 to 80 of about 999,557 (248)
Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. [PDF]
Nicotinamide adenine dinucleotide (NAD) is a cofactor involved in a wide range of cellular metabolic processes and is a key metabolite required for tumor growth.
Yang Xiao+6 more
doaj +1 more source
Bifurcation analysis of a model of the budding yeast cell cycle [PDF]
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. We show that Clb2-dependent kinase exhibits bistability (stable steady states of high or low kinase activity).
arxiv +1 more source
Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase
NAD kinase (NADK) is a crucial enzyme for production of NADP+. ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P) and is employed in industrial mass production ...
Y. Nakamichi+3 more
semanticscholar +1 more source
Properties of a Protein Activator of NAD Kinase from Plants [PDF]
Purification of pea (Pisum sativum) seedling NAD kinase by DEAE-cellulose column chromatography resulted in loss of activity, due to dissociation of an activator from the enzyme. The purified enzyme preparation, which was almost completely inactive, regained the activity when the activator was added back.The activator was purified 320-fold by ion ...
Shoshi Muto, Shigetoh Miyachi
openaire +3 more sources
Central metabolism is the engine of plant biomass, supplying fruit growth with building blocks, energy, and biochemical cofactors. Among metabolic cornerstones, nicotinamide adenine dinucleotide (NAD) is particularly pivotal for electron transfer through
Guillaume Decros+16 more
doaj +1 more source
The Role of Oxidative Stress in the Pathogenesis of Diabetic Vascular Complications [PDF]
Oxidative stress has been paid increasing attention to as an important causative factor for diabetic vascular complications. Among possible various sources, accumulating evidence has indicated that NAD(P)H oxidase may be the most important source for ...
Shuji Sasaki, Toyoshi Inoguchi
doaj +1 more source
Background Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active ...
Craig L. Doig+13 more
doaj +1 more source
Molecular properties, functions, and potential applications of NAD kinases [PDF]
NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of
Feng Shi+3 more
openaire +3 more sources
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and ...
Wolfram Tempel+10 more
doaj +1 more source
Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases [PDF]
Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability and metabolism. Although these NAD(+)-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated signaling targets remain under-studied.
Yeung, Fan+9 more
openaire +4 more sources