Results 51 to 60 of about 33,309 (204)
BiomoleculesNicotinamide adenine dinucleotide (NAD) is a critical cofactor in mitochondrial energy production. The NADH/NAD+ ratio, reflecting the balance between NADH (reduced) and NAD+ (oxidized), is a key marker for the severity of mitochondrial diseases.
Tamaki Ishima +12 more
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(A) NADH with various building blocks and dihedral angles. (B) NADH-InhA.
, 2015 (A) NADH with various building blocks and dihedral angles. (B) NADH-InhA.
Vivek Kumar (261698) +1 more
core +1 more source
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source
Why is the tumor microenvironment disordered by NADH/NAD+ imbalance and how can we intervene?
Redox BiologyNADH and NAD+ are crucial redox cofactors in biological systems, participating in the mitochondrial respiratory chain and playing significant roles in various metabolic processes.
Jing Li +5 more
doaj +1 more source
An NADH dependent reductase for isolated enzyme and whole cell catalysis. [PDF]
, 2006 Isolated enzymes and whole cell biocatalysts can both be applied for the synthesis of chiral hydroxy compounds. It is hypothesized that whole cells can easily be employed for such reactions using simple technology which is robust.
Shorrock, Vicky Jane, Shorrock, V.J.
core
Free and bound NADH distribution within NPSCs.
, 2013 Two-photon fluorescence intensity images (a) and free/bound NADH FLIM maps (b) of the E12 NPSCs excited at 740 nm (c) FLIM phasor plot of E12 NPSCs autofluorescence. A linear cluster represents relative concentrations of free NADH (purple) and bound NADH
Chiara Stringari (300545) +3 more
core +1 more source
Advanced Science, EarlyView.Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao +20 more
wiley +1 more source
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress
Nature Communications, 2022 Reductive stress, reflected by the elevated intracellular NADH/NAD+ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD+ and NADPH/NADP+, and identify purine ...
Ronghui Yang +8 more
doaj +1 more source
Advanced Science, EarlyView.Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit +10 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2014 Soluble water-forming NAD(P)H oxidases constitute a promising NAD(P)+ regeneration method as they only need oxygen as cosubstrate and produce water as sole byproduct. Moreover, the thermodynamic equilibrium of O2 reduction is a valuable driving force for
Barbara Petschacher +7 more
doaj +1 more source