Results 201 to 210 of about 141,947 (341)

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, Volume 14, Issue 12, December 2025.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Solution structure of HndAc: A thioredoxin‐like domain involved in the NADP‐reducing hydrogenase complex

, 2006
Matthieu Nouailler, Xavier Morelli, Olivier Bornet, Bernard Chétrit, Zorah Dermoun, Françoise Guerlesquin   +5 more
openalex   +1 more source

Control of NADP⁺‐specific isocitrate dehydrogenase from acinetobacter by nucleotides [PDF]

, 1976
H.‐P. Kleber, H. Aurich
openalex   +1 more source

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases.

ACS Synthetic Biology, 2017
Jackson K. B. Cahn, Caroline A. Werlang, Armin Baumschlager, S. Brinkmann-Chen, S. L. Mayo, F. Arnold   +5 more
semanticscholar   +1 more source

Crystal structure of a short‐chain dehydrogenase from Brucella ovis with apo and coenzyme NAD+‐bound protomer chains

Acta Crystallographica Section F, Volume 81, Issue 12, Page 487-494, December 2025.
This article describes the structural characterization of a short‐chain dehydrogenase from the pathogenic bacterium Brucella ovis. In this manuscript, two structures are described: the structure of the apo protein and a structure containing the coenzyme NAD+.Short‐chain dehydrogenases (SDRs) are a family of NAD(P)‐dependent enzymes involved in redox ...
Sean P. Zupko, Amelia T. Konstanty, Steve J. Mayclin, Ryan Choi, Dmitry Serbzhinskiy, Emily Robles, Victoria Moses, Lynn K. Barrett, Wesley C. Van Voorhis, Tom E. Edwards, Peter J. Myler, Andrew T. Torelli, Jarrod B. French, Katherine A. Hicks   +13 more
wiley   +1 more source

Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
In this prospective study of UK Biobank participants, type 2 diabetes (T2DM) was associated with poorer cognitive performance and a 2.13‐fold higher risk of incident dementia over 15 years. Four‐way decomposition models including 2923 proteomic, and KEGG pathway analyses, were used to implicate biological pathways in the association between T2DM and ...
Sofia E. Perfetto, Myuri Ruthirakuhan, Si Won Ryoo, Yuen Yan Wong, Lisa Y. Xiong, Natasha Z. Anita, Nathanael A. Caveney, Landon J. Edgar, John W. Newman, Hugo Cogo‐Moreira, Walter Swardfager   +10 more
wiley   +1 more source

Controversies in NEN: An ENETS position statement on nutritional support in neuroendocrine neoplasms

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under‐recognised and under‐treated condition in patients with NEN, and there are limited data available on the ...
Simona Grozinsky‐Glasberg, Johannes Hofland, Stephanie Alband, Yasmin Chotai de Lima, Adina Croitoru, Wanda Geilvoet, Peter Igaz, Beata Kos‐Kudła, Guenter J. Krejs, Alessandro Laviano, Francesco Panzuto, Anguraj Sadanandam, Ana Paula Santos, Staffan Welin, Rajaventhan Srirajaskanthan, V. Ambrosini, D. K. Bartsch, E. Baudin, N. Begum, E. Christ, J. Cros, T. Denecke, C. M. Deroose, C. Dromain, M. Falconi, N. Fazio, L. Fernandez‐Cuesta, R. Garcia‐Carbonero, A. Grossman, G. Kaltsas, A. Kasajima, A. Kjaer, G. Klöppel, U. P. Knigge, A. Lamarca, S. W. Langer, T. V. Luong, W. Martin, M. McNamara, D. O'Toole, S. Partelli, M. Pavel, A. Perren, R. Salazar, J. Schrader, H. Sorbye, A. Sowa‐Staszczak, E.‐J. Speel, P. Stalberg, M. Tesselaar, E. Tiensuu Janson, M. Tsoli, M. Volante, T. Walter   +53 more
wiley   +1 more source

Structural determinants for red‐shifted absorption in higher‐plants Photosystem I

New Phytologist, Volume 248, Issue 5, Page 2331-2346, December 2025.
Summary Higher plants Photosystem I absorbs far‐red light, enriched under vegetation canopies, through long‐wavelength Chls to enhance photon capture. Far‐red absorption originates from Chl pairs within the Lhca3 and Lhca4 subunits of the LHCI antenna, known as the ‘red cluster’, including Chls a603 and a609.
Stefano Capaldi, Zeno Guardini, Daniele Montepietra, Vittorio Flavio Pagliuca, Antonello Amelii, Elena Betti, Chris John, Laura Pedraza‐González, Lorenzo Cupellini, Benedetta Mennucci, Diane Marie Valerie Bonnet, Antonio Chaves‐Sanjuan, Luca Dall'Osto, Roberto Bassi   +13 more
wiley   +1 more source

Dynamics of Neutrophilic Granulocyte’s NADand NADP-Dependent Dehydrogenases Activity in Athletes [PDF]

, 2013
Savchenko Andrei A., Bazarin Kirill P.
openalex   +1 more source

Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status. [PDF]

Int J Mol Sci
Faludi T, Krakko D, Nolan J, Hanczko R, Patel A, Oaks Z, Ruggiero E, Lewis J, Wang X, Huang TT, Molnar-Perl I, Perl A.   +11 more
europepmc   +1 more source