Results 231 to 240 of about 143,400 (355)

Myeloid‐Derived CD38 Mediates Age‐Related Endometrial Aging Through NAD+ Depletion

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
An increased population of CD38+ macrophages, accompanied by a marked decline in stromal cell NAD+ levels, serves as key hallmarks of endometrial aging in aged mice. Pharmacological and genetic interventions revealed that macrophage‐derived CD38 is a principal driver of uterine NAD+ depletion, thereby accelerating stromal cell senescence and impairing ...
Lun Hua   +16 more
wiley   +1 more source

Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status. [PDF]

open access: yesInt J Mol Sci
Faludi T   +11 more
europepmc   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 96-112, January 2026.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

Transcriptomic and Functional Comparison of Cells Isolated From Healthy and Degenerated Ovine Intervertebral Discs

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, yet its cellular and molecular mechanisms remain incompletely understood. Sheep represent a valuable in vivo and ex vivo model for IVDD due to their anatomical and biomechanical similarities with humans and the possibility to access disc samples at early ...
Paul Humbert   +10 more
wiley   +1 more source

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