Results 51 to 60 of about 122,170 (318)

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Characterisation of components and mechanisms involved in redox-regulation of protein import into chloroplasts [PDF]

, 2009
The vast majority of chloroplast proteins is encoded in the nucleus and thus has to be posttranslationally imported into the organelle, a process that is facilitated by two multimeric protein machineries, the Toc and Tic complexes (translocon at the ...
Stengel, Anna
core  

Characteristics of C-4 photosynthesis in stems and petioles of C-3 flowering plants [PDF]

, 2002
Most plants are known as C-3 plants because the first product of photosynthetic CO2 fixation is a three-carbon compound. C-4 plants, which use an alternative pathway in which the first product is a four-carbon compound, have evolved independently many ...
A Ben Zioni, AR Ashton, AR Vuorinen, EA Kinsman, ET Nilsen, J Gerendas, J Schaaf, JA Raven, JA Raven, JC Thomas, JE Keeley, JE Keeley, JM Hibberd, JM Hibberd, JR Reinfelder, JS Pate, K Esau, M Calvin, MD Cramer, MD Cramer, MD Hatch, PD Moore, PJ Lea, RF Sage, RK Monson, RP Walker, S Rawsthorne, S Rawsthorne, S Rawsthorne, Z Gao   +29 more
core   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

National Atmospheric Deposition Program 2006 Annual Summary [PDF]

, 2007
published or submitted for publicationis peer ...
National Atmospheric Deposition Program
core  

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

Nature Communications
The NADPH/NADP+ redox couple is central to metabolism and redox signalling. NADP redox state is differentially regulated by distinct enzymatic machineries at the subcellular compartment level.
Marie Scherschel, Jan-Ole Niemeier, Lianne J. H. C. Jacobs, Markus D. A. Hoffmann, Anika Diederich, Christopher Bell, Pascal Höhne, Sonja Raetz, Johanna B. Kroll, Janina Steinbeck, Sophie Lichtenauer, Jan Multhoff, Jannik Zimmermann, Tanmay Sadhanasatish, R. Alexander Rothemann, Carsten Grashoff, Joris Messens, Emmanuel Ampofo, Matthias W. Laschke, Jan Riemer, Leticia Prates Roma, Markus Schwarzländer, Bruce Morgan   +22 more
doaj   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Ecophysiological traits of grasses: resolving the effects of photosynthetic pathway and phylogeny [PDF]

, 2009
C4 photosynthesis is an important example of convergent evolution in plants, having arisen in eudicots, monocots and diatoms. Comparisons between such diverse groups are confounded by phylogenetic and ecological differences, so that only broad ...
Brad S. Ripley, Colin P. Osborne, F. I. Woodward, Mark Rees, Rob Freckleton, Samuel H. Taylor, Stephen P. Hulme   +6 more
core   +2 more sources

Short-Term Low Temperature Induces Nitro-Oxidative Stress that Deregulates the NADP-Malic Enzyme Function by Tyrosine Nitration in Arabidopsis thaliana

Antioxidants, 2019
Low temperature (LT) negatively affects plant growth and development via the alteration of the metabolism of reactive oxygen and nitrogen species (ROS and RNS).
Juan C. Begara-Morales, Beatriz Sánchez-Calvo, María V. Gómez-Rodríguez, Mounira Chaki, Raquel Valderrama, Capilla Mata-Pérez, Javier López-Jaramillo, Francisco J. Corpas, Juan B. Barroso   +8 more
doaj   +1 more source