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HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Synthesis of thermostable artificial nicotinamide cofactors: carba-NAD<sup>+</sup> and carba-NADP. [PDF]

open access: yesRSC Chem Biol
Dsouza Z   +5 more
europepmc   +1 more source

Structure and Function of NAD Kinase and NADP Phosphatase: Key Enzymes That Regulate the Intracellular Balance of NAD(H) and NADP(H) [PDF]

open access: yesBioscience, Biotechnology and Biochemistry, 2008
The functions of NAD(H) (NAD(+) and NADH) and NADP(H) (NADP(+) and NADPH) are undoubtedly significant and distinct. Hence, regulation of the intracellular balance of NAD(H) and NADP(H) is important. The key enzymes involved in the regulation are NAD kinase and NADP phosphatase. In 2000, we first succeeded in identifying the gene for NAD kinase, thereby
Shigeyuki Kawai, Murata Kousaku
exaly   +3 more sources
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Inter-domain interaction of ferredoxin-NADP+ reductase important for the negative cooperativity by ferredoxin and NADP(H)

The Journal of Biochemistry, 2023
Summary (Abstract) Ferredoxin-NADP+ reductase (FNR) in plants receives electrons from ferredoxin (Fd) and converts NADP+ to NADPH. The affinity between FNR and Fd is weakened by the allosteric binding of NADP(H) on FNR, which is considered as a part of negative cooperativity.
Yoko, Kimata-Ariga   +2 more
openaire   +2 more sources

Structural and functional diversity of ferredoxin-NADP+ reductases [PDF]

open access: yesArchives of Biochemistry and Biophysics, 2008
Although all ferredoxin-NADP+ reductases (FNRs) catalyze the same reaction, i.e. the transfer of reducing equivalents between NADP(H) and ferredoxin, they belong to two unrelated families of proteins: the plant-type and the glutathione reductase-type of ...
Alessandro Aliverti   +2 more
exaly   +2 more sources

Structural elucidation of the NADP(H) phosphatase activity of staphylococcal dual-specific IMPase/NADP(H) phosphatase

Acta Crystallographica Section D Structural Biology, 2016
NADP(H)/NAD(H) homeostasis has long been identified to play a pivotal role in the mitigation of reactive oxygen stress (ROS) in the intracellular milieu and is therefore critical for the progression and pathogenesis of many diseases. NAD(H) kinases and NADP(H) phosphatases are two key players in this pathway.
Sudipta, Bhattacharyya   +4 more
openaire   +2 more sources

Inhibition of NAD(H)/NADP(H) — requiring enzymes by aurintricarboxylic acid

Toxicology Letters, 1995
Aurintricarboxylic acid (ATA), an inhibitor of Ca(2+)-dependent endonuclease activity, is often used to implicate a role for increased intracellular calcium in mechanistic toxicology studies. We report here on the ability of ATA to inhibit the activity of several NAD(H)/NADP(H)-requiring enzymes (purified or cellular homogenates), including lactic ...
D C, Thompson, M, Reed
openaire   +2 more sources

The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase

Molecular and Cellular Biochemistry, 2010
Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. In this study, we measure the rate of cofactor utilization by bovine GDH when both cofactors are present. Methods for both reaction directions were developed, and for the first time, to our knowledge,
Jason R, Treberg   +2 more
openaire   +2 more sources

PHARMACOLOGICAL ACTIONS OF THE COENZYMES NAD(H) AND NADP(H) ON THE RAT ANOCOCCYGEUS MUSCLE

Clinical and Experimental Pharmacology and Physiology, 1994
SUMMARY1. The pharmacological actions of the oxidized and reduced forms of nicotinamide‐adenosine dinucleotide (NAD, NADH) and nicotinamide‐adenosine dinucleotide phosphate (NADP, NADPH) were studied on rat isolated anococcygeus muscles.2. The actions of the two nucleotides were different, but there were no apparent qualitative differences between the ...
A, Najbar, C G, Li, M J, Rand
openaire   +2 more sources

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