Results 1 to 10 of about 175,606 (264)

NADPH Dehydrogenase Gene Regulates Energy Distribution and Fatty Acid Metabolism During Fruiting Body Formation in the Filamentous Fungus Podospora anserina [PDF]

open access: yesMicrobial Biotechnology
Nicotinamide adenine dinucleotide phosphate (NADPH) dehydrogenase is an oxidoreductase involved in many physiological processes and metabolic pathways. However, its role in filamentous fungal physiology is still unclear.
Yanling Qiu   +6 more
doaj   +2 more sources

Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition

open access: yesRedox Biology
Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive.
, Jun-Chao Wu
exaly   +3 more sources

Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

open access: yesFrontiers in Bioscience-Landmark, 2022
Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen   +5 more
doaj   +1 more source

The Possibility of Destruction of Cellular NADPH in the Presence of Free Fe(II) Ion, Arsine, and Other Hazardous Species [PDF]

open access: yesResearch in Molecular Medicine, 2022
Background: As the nicotinamide adenine dinucleotide phosphate (NADPH) is the key natural electron generator of the alive cells, investigation of the possibility of inactivation or even destruction of it by hazardous chemical molecules or ions seems to ...
Seyyed Amir Siadati   +2 more
doaj  

Serum of limb remote ischemic postconditioning inhibits fMLP-triggered activation and reactive oxygen species releasing of rat neutrophils

open access: yesRedox Report, 2021
Objectives The study explores the protective role of the peripheral serum of limb remote ischemic postconditioning (LRIP) in reducing the reactive oxygen species (ROS) levels and neutrophil activation, which are responsible for the deleterious ...
Gangling Chen   +7 more
doaj   +1 more source

Glucose as a Major Antioxidant: When, What for and Why It Fails?

open access: yesAntioxidants, 2020
A human organism depends on stable glucose blood levels in order to maintain its metabolic needs. Glucose is considered to be the most important energy source, and glycolysis is postulated as a backbone pathway.
Andriy Cherkas   +4 more
doaj   +1 more source

NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs

open access: yesBiomolecular Concepts, 2022
Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and oxidative stress appear implicated ...
Posadino Anna Maria   +7 more
doaj   +1 more source

Increasing NADPH impairs fungal H2O2 resistance by perturbing transcriptional regulation of peroxiredoxin

open access: yesBioresources and Bioprocessing, 2022
NADPH provides the reducing power for decomposition of reactive oxygen species (ROS), making it an indispensable part during ROS defense. It remains uncertain, however, if living cells respond to the ROS challenge with an elevated intracellular NADPH ...
Jingyi Li   +7 more
doaj   +1 more source

Limitations of Deuterium-Labelled Substrates for Quantifying NADPH Metabolism in Heterotrophic Arabidopsis Cell Cultures

open access: yesMetabolites, 2019
NADPH is the primary source of cellular reductant for biosynthesis, and strategies for increasing productivity via metabolic engineering need to take account of the requirement for reducing power.
Edward N. Smith   +3 more
doaj   +1 more source

The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target

open access: yesJournal of Hepatocellular Carcinoma, 2021
Xiangqian Guan, Yuyan Lu, Heping Zhu, Shuqi Yu, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Zhenyu Yin Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular ...
Guan X   +7 more
doaj  

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