Results 31 to 40 of about 175,216 (165)

Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase [PDF]

Biochemical Journal, 2005
The phagocytic NADPH oxidase generates superoxide by transferring electrons from cytosolic NADPH to extracellular O2. The activity of the oxidase at the plasma membrane can be measured as electron current (Ie), and the voltage dependence of Ie was recently reported to exhibit a strong rectification in human eosinophils, with the currents being nearly ...
Petheo, Gábor L, Demaurex, Nicolas
openaire   +3 more sources

Oligo-carrageenan kappa increases NADPH, ascorbate and glutathione syntheses and TRR/TRX activities enhancing photosynthesis, basal metabolism, and growth in Eucalyptus trees

Frontiers in Plant Science, 2014
In order to analyze the effect of OC kappa in redox status, photosynthesis, basal metabolism and growth in Eucalyptus globulus, trees were treated with water (control), with OC kappa at 1 mg mL-1, or treated with inhibitors of NAD(P)H, ascorbate (ASC ...
Alberto eGonzález, Fabiola eMoenne, Melissa eGómez, Claudio A. Sáez, Rodrigo A Contreras, Alejandra eMoenne   +5 more
doaj   +1 more source

Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. [PDF]

PLoS ONE, 2013
The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses.
Heidi E Godoy, A Nazmul H Khan, R Robert Vethanayagam, Melissa J Grimm, Kelly L Singel, Nonna Kolomeyevskaya, Kevin J Sexton, Anupama Parameswaran, Scott I Abrams, Kunle Odunsi, Brahm H Segal   +10 more
doaj   +1 more source

The cytosolic subunit p67^phox of the NADPH‐oxidase complex does not bind NADPH [PDF]

FEBS Letters, 2009
The NADPH‐oxidase of phagocytic cells is a multicomponent enzyme that generates superoxide. It comprises a membrane flavocytochrome b 558 and four cytosolic proteins; p67phox, p47phox, p40phox and Rac. The NADPH‐binding site of this complex was shown to be located on the flavocytochrome b 558. However, a number of studies have suggested the presence of
Baciou, Laura, Erard, Marie, Dagher, Marie-Claire, Bizouarn, Tania, Tania.Bizouarn@u-Psud.Fr   +3 more
openaire   +3 more sources

Novel mutations in NCF4 gene confer non-classic chronic granulomatous disease with disseminated histoplasmosis in a Colombian child

Revista Alergia México, 2018
Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to early-onset life-threatening bacterial and fungal infections as well as dysregulated chronic inflammation.
Carlos Andrés Arango-Franco, Alejandro Nieto-Patlán, Marcela Moncada-Vélez, Jesús Armando Álvarez, Carmen Oleaga-Quinta, Caroline Deswarte, Juan Fernando Alzate, Felipe Cabarcas, Carlos Garcés, Julio César Orrego, Susana Pamela Mejía, Luz Elena Cano, Jean-Laurent Casanova, Jacinta Bustamante, José Luis Franco, Andrés Augusto Arias   +15 more
doaj  

A Role for Reactive Oxygen Species Produced by NADPH Oxidases in the Embryo and Aleurone Cells in Barley Seed Germination.

PLoS ONE, 2015
Reactive oxygen species (ROS) promote the germination of several seeds, and antioxidants suppress it. However, questions remain regarding the role and production mechanism of ROS in seed germination. Here, we focused on NADPH oxidases, which produce ROS.
Yushi Ishibashi, Shinsuke Kasa, Masatsugu Sakamoto, Nozomi Aoki, Kyohei Kai, Takashi Yuasa, Atsushi Hanada, Shinjiro Yamaguchi, Mari Iwaya-Inoue   +8 more
doaj   +1 more source

NADPH oxidase limits innate immune responses in the lungs in mice. [PDF]

PLoS ONE, 2010
Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal ...
Brahm H Segal, Wei Han, Jennifer J Bushey, Myungsoo Joo, Zahida Bhatti, Joy Feminella, Carly G Dennis, R Robert Vethanayagam, Fiona E Yull, Maegan Capitano, Paul K Wallace, Hans Minderman, John W Christman, Michael B Sporn, Jefferson Chan, Donald C Vinh, Steven M Holland, Luigina R Romani, Sarah L Gaffen, Michael L Freeman, Timothy S Blackwell   +20 more
doaj   +1 more source

Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione

ASN Neuro, 2016
The pentose phosphate pathway is the main source of NADPH, which by reducing oxidized glutathione, contributes to antioxidant defenses. Although oxidative stress plays a major role in white matter injury, significance of NADPH for oligodendrocyte ...
Ewa Kilanczyk, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman   +3 more
doaj   +1 more source

Expression and cellular distribution of NADPH-diaphorase and nitric oxide synthases in the porcine uterus during early pregnancy.

Folia Histochemica et Cytobiologica, 2008
Nitric oxide plays a key role in the regulation of various female reproductive processes such as ovulation, implantation and myometrial relaxation. The aim of the present study was to determine the histochemical activity and cellular localization of ...
Aneta Andronowska, Marcin Chruściel
doaj   +1 more source

Dynamic and Static Regulation of Nicotinamide Adenine Dinucleotide Phosphate: Strategies, Challenges, and Future Directions in Metabolic Engineering

Molecules
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial cofactor in metabolic networks. The efficient regeneration of NADPH is one of the limiting factors for productivity in biotransformation processes.
Nana Ding, Zenan Yuan, Lei Sun, Lianghong Yin   +3 more
doaj   +1 more source