Results 1 to 10 of about 51,168 (257)
The Role of the Pentose Phosphate Pathway in Diabetes and Cancer [PDF]
Frontiers in Endocrinology, 2020 The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway.
Tongxin Ge +5 more
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Pentose phosphate pathway inhibition metabolically reprograms CD8+ T cells and disrupts CNS autoimmunity [PDF]
JCI InsightMultiple sclerosis is characterized by CNS infiltration of autoreactive immune cells that drive both acute inflammatory demyelination and chronic progressive axonal and neuronal injury.
Ethan M. Grund +6 more
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Cell Reports, 2018 Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. Cells
Susan J. Gelman +6 more
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Pulsatilla Powder Ameliorates Damp-Heat Diarrhea in Piglets Through the Regulation of Intestinal Mucosal Barrier and the Pentose Phosphate Pathway Involving G6PD and NOX [PDF]
Veterinary SciencesDamp-heat diarrhea (DHD) in piglets presents as diarrhea and intestinal bleeding, significantly affecting both piglet health and the pig industry. Pulsatilla powder (PP), a herbal formulation composed of Pulsatilla, Rhizoma Coptidis, Phellodendron Bark ...
Yunqi Qu +5 more
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Frontiers in Public Health, 2022 This study analyzed the differences in subtypes and characteristics of advanced lung adenocarcinoma (LUAD) patients based on the pentose phosphate metabolic pathway-related long non-coding RNAs (lncRNAs), along with their potential regulatory mechanisms.
Chuan Liu, Yongjie Wang
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Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose. [PDF]
PLoS ONE, 2016 The efficient use of hemicellulose in the plant cell wall is critical for the economic conversion of plant biomass to renewable fuels and chemicals. Previously, the yeast Saccharomyces cerevisiae has been engineered to convert the hemicellulose-derived ...
Kulika Chomvong +5 more
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Advanced Science, 2023 Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a ...
Menglang Yuan +17 more
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Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
Cells, 2021 The pentose phosphate pathway (PPP) is divided into an oxidative branch that makes pentose phosphates and a non-oxidative branch that consumes pentose phosphates, though the non-oxidative branch is considered reversible.
Thomas D. Sharkey
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Queueing theory model of pentose phosphate pathway
Scientific Reports, 2022 Due to its role in maintaining the proper functioning of the cell, the pentose phosphate pathway (PPP) is one of the most important metabolic pathways.
Sylwester M. Kloska +7 more
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Frontiers in Microbiology, 2022 The strict human pathogen Streptococcus pyogenes causes infections of varying severity, ranging from self-limiting suppurative infections to life-threatening diseases like necrotizing fasciitis or streptococcal toxic shock syndrome.
Philip Eisenberg +16 more
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